Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease

Koichi Banno, Shutaro Nakaaki, Junko Sato, Katsuyoshi Torii, Jin Narumoto, Jun Miyata, Nobutsugu Hirono, Toshi A. Furukawa, Masaru Mimura, Tatsuo Akechi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Agitated behaviors are frequently observed in patients with Alzheimer disease (AD). The neural substrate underlying the agitated behaviors in dementia is unclear. We hypothesized that different dimensions of agitated behaviors are mediated by distinct neural systems. Methods: All the patients (n=32) underwent single photon emission computed tomography (SPECT). Using the Agitated Behavior in Dementia scale, we identified the relationships between regional cerebral blood flow (rCBF) patterns and the presence of each of three dimensions of agitated behavior (physically agitated behavior, verbally agitated behavior, and psychosis symptoms) in AD patients. Statistical parametric mapping (SPM) software was used to explore these neural correlations. Results: Physically agitated behavior was significantly correlated with lower rCBF values in the right superior temporal gyrus (Brodmann 22) and the right inferior frontal gyrus (Brodmann 47). Verbally agitated behavior was significantly associated with lower rCBF values in the left inferior frontal gyrus (Brodmann 46, 44) and the left insula (Brodmann 13). The psychosis symptoms were significantly correlated with lower rCBF values in the right angular gyrus (Brodmann 39) and the right occipital lobe (Brodmann 19). Conclusion: Our results support the hypothesis that three different agitated behaviors may represent distinct neural networks in AD patients.

Original languageEnglish
Pages (from-to)339-348
Number of pages10
JournalNeuropsychiatric Disease and Treatment
Volume10
DOIs
Publication statusPublished - 2014 Feb 17

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Alzheimer Disease
Cerebrovascular Circulation
Regional Blood Flow
Prefrontal Cortex
Psychotic Disorders
Dementia
Occipital Lobe
Parietal Lobe
Temporal Lobe
Single-Photon Emission-Computed Tomography
Software

Keywords

  • Physically agitated behavior
  • Psychosis
  • SPECT
  • Verbally agitated behavior

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Banno, K., Nakaaki, S., Sato, J., Torii, K., Narumoto, J., Miyata, J., ... Akechi, T. (2014). Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease. Neuropsychiatric Disease and Treatment, 10, 339-348. https://doi.org/10.2147/NDT.S57522

Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease. / Banno, Koichi; Nakaaki, Shutaro; Sato, Junko; Torii, Katsuyoshi; Narumoto, Jin; Miyata, Jun; Hirono, Nobutsugu; Furukawa, Toshi A.; Mimura, Masaru; Akechi, Tatsuo.

In: Neuropsychiatric Disease and Treatment, Vol. 10, 17.02.2014, p. 339-348.

Research output: Contribution to journalArticle

Banno, K, Nakaaki, S, Sato, J, Torii, K, Narumoto, J, Miyata, J, Hirono, N, Furukawa, TA, Mimura, M & Akechi, T 2014, 'Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease', Neuropsychiatric Disease and Treatment, vol. 10, pp. 339-348. https://doi.org/10.2147/NDT.S57522
Banno, Koichi ; Nakaaki, Shutaro ; Sato, Junko ; Torii, Katsuyoshi ; Narumoto, Jin ; Miyata, Jun ; Hirono, Nobutsugu ; Furukawa, Toshi A. ; Mimura, Masaru ; Akechi, Tatsuo. / Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease. In: Neuropsychiatric Disease and Treatment. 2014 ; Vol. 10. pp. 339-348.
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