Neural ECM and synaptogenesis

Anne Heikkinen, Taina Pihlajaniemi, Andreas Faissner, Michisuke Yuzaki

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Chemical synapses allow neurons to perform complex computations and regulate other systems of the body. At a chemical synapse, pre- and postsynaptic sites are separated by a small space (the synaptic cleft) and surrounded by astrocytes. The basement membrane (BM), a sheetlike, specialized extracellular matrix (ECM), is found ubiquitously in the PNS. It has become clear that the ECMs not only play a structural role but also serve as barriers and filters in the PNS and CNS. Moreover, proteoglycans and tenascin family proteins in the ECM regulate synapse formation and synaptic plasticity. Although CNS synapses lack the BMs, recent results indicate that the BM-associated collagens are also present in the CNS synaptic cleft and affect synaptogenesis in both the CNS and the PNS. The C1q domain-containing family proteins are important components of the CNS synaptic cleft in regulating synapse formation, maintenance, and the pruning process. The ECM is regarded as a crucial component of the tetrapartite synapse, consisting of pre- and postsynaptic neurons, astrocyte, and ECM.

Original languageEnglish
Pages (from-to)29-51
Number of pages23
JournalProgress in Brain Research
Volume214
DOIs
Publication statusPublished - 2014

Fingerprint

Synapses
Extracellular Matrix
Basement Membrane
Astrocytes
Tenascin
Neurons
Neuronal Plasticity
Extracellular Matrix Proteins
Proteoglycans
Collagen
Maintenance
Proteins

Keywords

  • Basement membrane
  • C1q
  • Cerebellum
  • Collagen
  • Neuromuscular junction
  • Perineuronal net
  • Proteoglycan
  • Retinal ganglion cell
  • Synaptogenesis
  • Tenascin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neural ECM and synaptogenesis. / Heikkinen, Anne; Pihlajaniemi, Taina; Faissner, Andreas; Yuzaki, Michisuke.

In: Progress in Brain Research, Vol. 214, 2014, p. 29-51.

Research output: Contribution to journalArticle

Heikkinen, Anne ; Pihlajaniemi, Taina ; Faissner, Andreas ; Yuzaki, Michisuke. / Neural ECM and synaptogenesis. In: Progress in Brain Research. 2014 ; Vol. 214. pp. 29-51.
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