Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference

Seiki Konishi, Junichi Chikazoe, Koji Jimura, Tomori Asari, Yasushi Miyashita

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Once one cognitive set dominates our behavior, it continues to influence subsequent behavior for a while even after a task to be performed is changed to another. Despite abundant knowledge of the inhibitory mechanisms that are recruited at the first trial after the change (the first inhibition trial), little is known about the inhibition of prolonged proactive interference from a previous set that lingers for several trials after the first inhibition trial. The present functional MRI study explored the neural mechanisms for inhibition of a previous set that were recruited after the first inhibition trial. A modified Wisconsin Card Sorting Test was used where "dual-match stimuli" were intermittently presented and allowed subjects to perform correctly based on previously appropriate, now inappropriate, responses. In response to the dual-match stimulus at "release" trials presented after the first inhibition trials, the subjects were transiently exempted from inhibiting the prolonged previous set. As expected from the exempted inhibitory demands, significant reaction time decrease was revealed in the release trials. Consistent with the behavioral results, transient signal decrease time-locked to the release trials was revealed in the left anterior part of the superior frontal sulcus. Moreover, the anterior prefrontal region was not sensitive to the task change, which exhibited a marked contrast to the left posterior inferior prefrontal region that showed significant signal changes in both events. These results revealed multiple inhibitory mechanisms in the lateral prefrontal cortex that are recruited in different temporal contexts of the interference from a previous cognitive set.

Original languageEnglish
Pages (from-to)12584-12588
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number35
DOIs
Publication statusPublished - 2005 Aug 30
Externally publishedYes

Fingerprint

Prefrontal Cortex
Proactive Inhibition
Neural Inhibition
Reaction Time
Magnetic Resonance Imaging
Inhibition (Psychology)

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference. / Konishi, Seiki; Chikazoe, Junichi; Jimura, Koji; Asari, Tomori; Miyashita, Yasushi.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 35, 30.08.2005, p. 12584-12588.

Research output: Contribution to journalArticle

Konishi, Seiki ; Chikazoe, Junichi ; Jimura, Koji ; Asari, Tomori ; Miyashita, Yasushi. / Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference. In: Proceedings of the National Academy of Sciences of the United States of America. 2005 ; Vol. 102, No. 35. pp. 12584-12588.
@article{9cc5434ae8924317acb389152e5b39d4,
title = "Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference",
abstract = "Once one cognitive set dominates our behavior, it continues to influence subsequent behavior for a while even after a task to be performed is changed to another. Despite abundant knowledge of the inhibitory mechanisms that are recruited at the first trial after the change (the first inhibition trial), little is known about the inhibition of prolonged proactive interference from a previous set that lingers for several trials after the first inhibition trial. The present functional MRI study explored the neural mechanisms for inhibition of a previous set that were recruited after the first inhibition trial. A modified Wisconsin Card Sorting Test was used where {"}dual-match stimuli{"} were intermittently presented and allowed subjects to perform correctly based on previously appropriate, now inappropriate, responses. In response to the dual-match stimulus at {"}release{"} trials presented after the first inhibition trials, the subjects were transiently exempted from inhibiting the prolonged previous set. As expected from the exempted inhibitory demands, significant reaction time decrease was revealed in the release trials. Consistent with the behavioral results, transient signal decrease time-locked to the release trials was revealed in the left anterior part of the superior frontal sulcus. Moreover, the anterior prefrontal region was not sensitive to the task change, which exhibited a marked contrast to the left posterior inferior prefrontal region that showed significant signal changes in both events. These results revealed multiple inhibitory mechanisms in the lateral prefrontal cortex that are recruited in different temporal contexts of the interference from a previous cognitive set.",
author = "Seiki Konishi and Junichi Chikazoe and Koji Jimura and Tomori Asari and Yasushi Miyashita",
year = "2005",
month = "8",
day = "30",
doi = "10.1073/pnas.0500585102",
language = "English",
volume = "102",
pages = "12584--12588",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "35",

}

TY - JOUR

T1 - Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference

AU - Konishi, Seiki

AU - Chikazoe, Junichi

AU - Jimura, Koji

AU - Asari, Tomori

AU - Miyashita, Yasushi

PY - 2005/8/30

Y1 - 2005/8/30

N2 - Once one cognitive set dominates our behavior, it continues to influence subsequent behavior for a while even after a task to be performed is changed to another. Despite abundant knowledge of the inhibitory mechanisms that are recruited at the first trial after the change (the first inhibition trial), little is known about the inhibition of prolonged proactive interference from a previous set that lingers for several trials after the first inhibition trial. The present functional MRI study explored the neural mechanisms for inhibition of a previous set that were recruited after the first inhibition trial. A modified Wisconsin Card Sorting Test was used where "dual-match stimuli" were intermittently presented and allowed subjects to perform correctly based on previously appropriate, now inappropriate, responses. In response to the dual-match stimulus at "release" trials presented after the first inhibition trials, the subjects were transiently exempted from inhibiting the prolonged previous set. As expected from the exempted inhibitory demands, significant reaction time decrease was revealed in the release trials. Consistent with the behavioral results, transient signal decrease time-locked to the release trials was revealed in the left anterior part of the superior frontal sulcus. Moreover, the anterior prefrontal region was not sensitive to the task change, which exhibited a marked contrast to the left posterior inferior prefrontal region that showed significant signal changes in both events. These results revealed multiple inhibitory mechanisms in the lateral prefrontal cortex that are recruited in different temporal contexts of the interference from a previous cognitive set.

AB - Once one cognitive set dominates our behavior, it continues to influence subsequent behavior for a while even after a task to be performed is changed to another. Despite abundant knowledge of the inhibitory mechanisms that are recruited at the first trial after the change (the first inhibition trial), little is known about the inhibition of prolonged proactive interference from a previous set that lingers for several trials after the first inhibition trial. The present functional MRI study explored the neural mechanisms for inhibition of a previous set that were recruited after the first inhibition trial. A modified Wisconsin Card Sorting Test was used where "dual-match stimuli" were intermittently presented and allowed subjects to perform correctly based on previously appropriate, now inappropriate, responses. In response to the dual-match stimulus at "release" trials presented after the first inhibition trials, the subjects were transiently exempted from inhibiting the prolonged previous set. As expected from the exempted inhibitory demands, significant reaction time decrease was revealed in the release trials. Consistent with the behavioral results, transient signal decrease time-locked to the release trials was revealed in the left anterior part of the superior frontal sulcus. Moreover, the anterior prefrontal region was not sensitive to the task change, which exhibited a marked contrast to the left posterior inferior prefrontal region that showed significant signal changes in both events. These results revealed multiple inhibitory mechanisms in the lateral prefrontal cortex that are recruited in different temporal contexts of the interference from a previous cognitive set.

UR - http://www.scopus.com/inward/record.url?scp=24644501200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24644501200&partnerID=8YFLogxK

U2 - 10.1073/pnas.0500585102

DO - 10.1073/pnas.0500585102

M3 - Article

C2 - 16107543

AN - SCOPUS:24644501200

VL - 102

SP - 12584

EP - 12588

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 35

ER -