Neural stem cells and regeneration of injured spinal cord

Hideyuki Okano, Seiji Okada, Masaya Nakamura, Yoshiaki Toyama

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Recent progress in the stem cell biology has led much insight into new therapeutic interventions aiming for the regeneration of the damaged central nervous system. The major strategies can be classified into two subgroups: (1) activation of endogenous neural stem cells, and (2) cell transplantation therapies. In either of these strategies, it is crucial to understand the underlying mechanisms of maintenance, activation, and differentiation of neural stem cells and subsequent process, including the migration, survival, and functional maturation of differentiated cells. In this paper, we would like to summarize our recent findings on the therapeutic interventions of the injured spinal cord, especially focusing on the development of treatment for the acute phase of spinal cord injury with anti-interleukin (IL)-6 receptor blocking antibody.

Original languageEnglish
Pages (from-to)1927-1931
Number of pages5
JournalKidney International
Volume68
Issue number5
DOIs
Publication statusPublished - 2005 Nov

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Spinal Cord Regeneration
Neural Stem Cells
Interleukin-6 Receptors
Blocking Antibodies
Cell Transplantation
Cell- and Tissue-Based Therapy
Spinal Cord Injuries
Cell Biology
Regeneration
Spinal Cord
Stem Cells
Therapeutics
Central Nervous System
Maintenance

ASJC Scopus subject areas

  • Nephrology

Cite this

Neural stem cells and regeneration of injured spinal cord. / Okano, Hideyuki; Okada, Seiji; Nakamura, Masaya; Toyama, Yoshiaki.

In: Kidney International, Vol. 68, No. 5, 11.2005, p. 1927-1931.

Research output: Contribution to journalArticle

Okano, Hideyuki ; Okada, Seiji ; Nakamura, Masaya ; Toyama, Yoshiaki. / Neural stem cells and regeneration of injured spinal cord. In: Kidney International. 2005 ; Vol. 68, No. 5. pp. 1927-1931.
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