Neural stem cells: The basic biology and prospects for brain repair

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Abstract

Neural stem cells (NSCs) are multipotential progenitor cells that have self-renewal activities. A single NSC is capable of generating various kinds of cells within the CNS, including neurons, astrocytes, and oligodendrocytes. Because of these characteristics, there is an increasing interest in NSCs and neural progenitor cells from the aspects of both basic developmental biology and therapeutic applications to the damaged brain. By understanding of nature of NSCs present in CNS, extracellular factors and signal transduction cascades involved in the differentiation and maintenance of NSCs, population dynamics and localizations of NSCs in embryonic and adult brains, prospective identification and isolation of NSCs, and induction of NSCs into particular neuronal phenotypes, which will be introduced in this review, it would be possible to develop a feasible strategy to manipulate cells in situ to treat the damaged brain.

Original languageEnglish
Pages (from-to)1036-1040
Number of pages5
JournalClinical Neurology
Volume41
Issue number12
Publication statusPublished - 2001 Dec 1

Keywords

  • Multipotency
  • Regional identity
  • Self-renewality
  • Transdifferentiation
  • Transplantation

ASJC Scopus subject areas

  • Clinical Neurology

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