Neuroimaging correlates of narcolepsy with cataplexy: A systematic review

Masataka Wada, Masaru Mimura, Yoshihiro Noda, Shotaro Takasu, Eric Plitman, Makoto Honda, Akiyo Natsubori, Kamiyu Ogyu, Ryosuke Tarumi, Ariel Graff-Guerrero, Shinichiro Nakajima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Recent developments in neuroimaging techniques have advanced our understanding of biological mechanisms underpinning narcolepsy. We used MEDLINE to retrieve neuroimaging studies to compare patients with narcolepsy and healthy controls. Thirty-seven studies were identified and demonstrated several replicated abnormalities: (1) gray matter reductions in superior frontal, superior and inferior temporal, and middle occipital gyri, hypothalamus, amygdala, insula, hippocampus, cingulate cortex, thalamus, and nucleus accumbens, (2) decreased fractional anisotropy in white matter of fronto-orbital and cingulate area, (3) reduced brain metabolism or cerebral blood flow in middle and superior frontal, and cingulate cortex (4) increased activity in inferior frontal gyri, insula, amygdala, and nucleus accumbens, and (5) N-acetylaspartate/creatine-phosphocreatine level reduction in hypothalamus. In conclusion, all the replicated findings are still controversial due to the limitations such as heterogeneity or size of the samples and lack of multimodal imaging or follow-up. Thus, future neuroimaging studies should employ multimodal imaging methods in a large sample size of patients with narcolepsy and consider age, duration of disease, age at onset, severity, human leukocyte antigen type, cerebrospinal fluid hypocretin levels, and medication intake in order to elucidate possible neuroimaging characteristic of narcolepsy and identify therapeutic targets.

Original languageEnglish
JournalNeuroscience Research
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Cataplexy
Narcolepsy
Neuroimaging
Gyrus Cinguli
Multimodal Imaging
Nucleus Accumbens
Amygdala
Prefrontal Cortex
Sample Size
Hypothalamus
Cerebrovascular Circulation
Occipital Lobe
Phosphocreatine
Creatine
Anisotropy
Frontal Lobe
HLA Antigens
Thalamus
Age of Onset
MEDLINE

Keywords

  • Diffusion tensor imaging (DTI)
  • Magnetic resonance imaging (MRI)
  • Positron emission tomography (PET)
  • Proton magnetic resonance spectroscopy (H-MRS)
  • Single photon emission computed tomography (SPECT)
  • Voxel-based morphometry (VBM)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuroimaging correlates of narcolepsy with cataplexy : A systematic review. / Wada, Masataka; Mimura, Masaru; Noda, Yoshihiro; Takasu, Shotaro; Plitman, Eric; Honda, Makoto; Natsubori, Akiyo; Ogyu, Kamiyu; Tarumi, Ryosuke; Graff-Guerrero, Ariel; Nakajima, Shinichiro.

In: Neuroscience Research, 01.01.2018.

Research output: Contribution to journalArticle

Wada, M, Mimura, M, Noda, Y, Takasu, S, Plitman, E, Honda, M, Natsubori, A, Ogyu, K, Tarumi, R, Graff-Guerrero, A & Nakajima, S 2018, 'Neuroimaging correlates of narcolepsy with cataplexy: A systematic review', Neuroscience Research. https://doi.org/10.1016/j.neures.2018.03.005
Wada, Masataka ; Mimura, Masaru ; Noda, Yoshihiro ; Takasu, Shotaro ; Plitman, Eric ; Honda, Makoto ; Natsubori, Akiyo ; Ogyu, Kamiyu ; Tarumi, Ryosuke ; Graff-Guerrero, Ariel ; Nakajima, Shinichiro. / Neuroimaging correlates of narcolepsy with cataplexy : A systematic review. In: Neuroscience Research. 2018.
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