Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis

Morinobu Seki, Shigeaki Suzuki, T. Iizuka, Toshihiko Shimizu, Y. Nihei, N. Suzuki, J. Dalmau

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

We report an 18-year-old woman with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, who developed psychiatric symptoms, progressive unresponsiveness, dyskinesias, hypoventilation, hypersalivation and seizures. Early removal of an ovarian teratoma followed by plasma exchange and corticosteroids resulted in a prompt neurological response and eventual full recovery. Serial analysis of antibodies to NR1/NR2B heteromers of the NMDAR showed an early decrease of serum titres, although the cerebrospinal fluid titres correlated better with clinical outcome. The patients' antibodies reacted with areas of the tumour that contained NMDAR-expressing tissue. Search for and removal of a teratoma should be promptly considered after the diagnosis of anti-NMDAR encephalitis.

Original languageEnglish
Pages (from-to)324-326
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume79
Issue number3
DOIs
Publication statusPublished - 2008 Mar

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Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Sialorrhea
Hypoventilation
Plasma Exchange
Antibodies
Teratoma
Dyskinesias
N-Methyl-D-Aspartate Receptors
Psychiatry
Cerebrospinal Fluid
Adrenal Cortex Hormones
Seizures
Serum
Neoplasms
Ovarian Teratoma

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis. / Seki, Morinobu; Suzuki, Shigeaki; Iizuka, T.; Shimizu, Toshihiko; Nihei, Y.; Suzuki, N.; Dalmau, J.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 79, No. 3, 03.2008, p. 324-326.

Research output: Contribution to journalArticle

Seki, Morinobu ; Suzuki, Shigeaki ; Iizuka, T. ; Shimizu, Toshihiko ; Nihei, Y. ; Suzuki, N. ; Dalmau, J. / Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis. In: Journal of Neurology, Neurosurgery and Psychiatry. 2008 ; Vol. 79, No. 3. pp. 324-326.
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