Neuronal alignment in a 3D neural microtube

Midori Negishi, Hiroaki Onoe, Akane Itou, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper describes the effect of geometrical changes in tube-shaped three-dimensional (3D) microenvironment on mouse neural stem cells (mNSCs) differentiating rate and neuronal alignment. We successfully fabricate three types of mNSC microtube structures by controlling the flow rate through double coaxial microfluidic device. Interestingly, we found that thin core diameter induces high neural differentiating rate and increases neuronal alignment in the 3D microenvironment. These results are significantly important information for 3D neuronal tissues formation from neural stem cells. We believe the neuronal alignment in the 3D microenvironment advances the applicability of the tube-shaped structure to tissue engineering, medical transplantation and stem cell biology.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages847-848
Number of pages2
ISBN (Electronic)9780979806483
Publication statusPublished - 2015
Externally publishedYes
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 2015 Oct 252015 Oct 29

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period15/10/2515/10/29

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Keywords

  • 3D culture
  • Neural network
  • Neural stem cell

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Negishi, M., Onoe, H., Itou, A., & Takeuchi, S. (2015). Neuronal alignment in a 3D neural microtube. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 847-848). Chemical and Biological Microsystems Society.