Neuronal migration in cortical development

Shigeaki Kanatani, Hidenori Tabata, Kazunori Nakajima

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Cortical formation in the developing brain is a highly complicated process involving neuronal production (through symmetric or asymmetric cell division) interaction of radial glia with neuronal migration, and multiple modes of neuronal migration. It has been convincingly demonstrated by numerous studies that radial glial cells are neural stem cells. However, the processes by which neurons arise from radial glia and migrate to their final destinations in vivo are not yet fully understood. Recent studies using time-lapse imaging of neuronal migration are giving investigators an increasingly more detailed understanding of the mitotic behavior of radial glia and the migrating behavior of their daughter cells. In this review, we describe recent progress in elucidating neuronal migration in brain formation and how neuronal migration is disturbed by mutations in genes that control this process.

Original languageEnglish
Pages (from-to)274-279
Number of pages6
JournalJournal of Child Neurology
Volume20
Issue number4
Publication statusPublished - 2005 Apr

Fingerprint

Neuroglia
Asymmetric Cell Division
Time-Lapse Imaging
Ependymoglial Cells
Neural Stem Cells
Brain
Cell Communication
Research Personnel
Neurons
Mutation
Genes

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Neuronal migration in cortical development. / Kanatani, Shigeaki; Tabata, Hidenori; Nakajima, Kazunori.

In: Journal of Child Neurology, Vol. 20, No. 4, 04.2005, p. 274-279.

Research output: Contribution to journalArticle

Kanatani, S, Tabata, H & Nakajima, K 2005, 'Neuronal migration in cortical development', Journal of Child Neurology, vol. 20, no. 4, pp. 274-279.
Kanatani, Shigeaki ; Tabata, Hidenori ; Nakajima, Kazunori. / Neuronal migration in cortical development. In: Journal of Child Neurology. 2005 ; Vol. 20, No. 4. pp. 274-279.
@article{064fcbf694e4447ebf9da47d9ec39558,
title = "Neuronal migration in cortical development",
abstract = "Cortical formation in the developing brain is a highly complicated process involving neuronal production (through symmetric or asymmetric cell division) interaction of radial glia with neuronal migration, and multiple modes of neuronal migration. It has been convincingly demonstrated by numerous studies that radial glial cells are neural stem cells. However, the processes by which neurons arise from radial glia and migrate to their final destinations in vivo are not yet fully understood. Recent studies using time-lapse imaging of neuronal migration are giving investigators an increasingly more detailed understanding of the mitotic behavior of radial glia and the migrating behavior of their daughter cells. In this review, we describe recent progress in elucidating neuronal migration in brain formation and how neuronal migration is disturbed by mutations in genes that control this process.",
author = "Shigeaki Kanatani and Hidenori Tabata and Kazunori Nakajima",
year = "2005",
month = "4",
language = "English",
volume = "20",
pages = "274--279",
journal = "Journal of Child Neurology",
issn = "0883-0738",
publisher = "SAGE Publications Inc.",
number = "4",

}

TY - JOUR

T1 - Neuronal migration in cortical development

AU - Kanatani, Shigeaki

AU - Tabata, Hidenori

AU - Nakajima, Kazunori

PY - 2005/4

Y1 - 2005/4

N2 - Cortical formation in the developing brain is a highly complicated process involving neuronal production (through symmetric or asymmetric cell division) interaction of radial glia with neuronal migration, and multiple modes of neuronal migration. It has been convincingly demonstrated by numerous studies that radial glial cells are neural stem cells. However, the processes by which neurons arise from radial glia and migrate to their final destinations in vivo are not yet fully understood. Recent studies using time-lapse imaging of neuronal migration are giving investigators an increasingly more detailed understanding of the mitotic behavior of radial glia and the migrating behavior of their daughter cells. In this review, we describe recent progress in elucidating neuronal migration in brain formation and how neuronal migration is disturbed by mutations in genes that control this process.

AB - Cortical formation in the developing brain is a highly complicated process involving neuronal production (through symmetric or asymmetric cell division) interaction of radial glia with neuronal migration, and multiple modes of neuronal migration. It has been convincingly demonstrated by numerous studies that radial glial cells are neural stem cells. However, the processes by which neurons arise from radial glia and migrate to their final destinations in vivo are not yet fully understood. Recent studies using time-lapse imaging of neuronal migration are giving investigators an increasingly more detailed understanding of the mitotic behavior of radial glia and the migrating behavior of their daughter cells. In this review, we describe recent progress in elucidating neuronal migration in brain formation and how neuronal migration is disturbed by mutations in genes that control this process.

UR - http://www.scopus.com/inward/record.url?scp=20044390555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20044390555&partnerID=8YFLogxK

M3 - Article

C2 - 15921226

AN - SCOPUS:20044390555

VL - 20

SP - 274

EP - 279

JO - Journal of Child Neurology

JF - Journal of Child Neurology

SN - 0883-0738

IS - 4

ER -