Neuropathology of supercentenarians - four autopsy case studies

Masaki Takao, Nobuyoshi Hirose, Yasumichi Arai, Ban Mihara, Masaru Mimura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Supercentenarians (aged 110 years old or more) are extremely rare in the world population (the number of living supercentenarians is estimated as 47 in the world), and details about their neuropathological information are limited. Based on previous studies, centenarians (aged 100-109 years old) exhibit several types of neuropathological changes, such as Alzheimer's disease and Lewy body disease pathology, primary age-related tauopathy, TDP-43 pathology, and hippocampal sclerosis. In the present study, we provide results from neuropathological analyses of four supercentenarian autopsy cases using conventional and immunohistochemical analysis for neurodegenerative disorders. In particular, we focused on the pathology of Alzheimer's disease and Lewy body disease, as well as the status of hippocampal sclerosis, TDP-43 pathology, aging-related tau astrogliopathy, and cerebrovascular diseases. Three cases were characterized as an "intermediate" level of Alzheimer's disease changes (NIA-AA guideline) and one was characterized as primary age-related tauopathy. TDP-43 deposits were present in the hippocampus in two cases. Neither Lewy body pathology nor hippocampal sclerosis was observed. Aging-related tau astrogliopathy was consistently observed, particularly in the basal forebrain. Small vessel diseases were also present, but they were relatively mild for cerebral amyloid-beta angiopathy and arteriolosclerosis. Although our study involved a small number of cases, the results provide a better understanding about human longevity. Neuropathological alterations associated with aging were mild to moderate in the supercentenarian brain, suggesting that these individuals might have some neuroprotective factors against aging. Future prospective studies and extensive molecular analyses are needed to determine the mechanisms of human longevity.

Original languageEnglish
Number of pages1
JournalActa neuropathologica communications
Volume4
Issue number1
DOIs
Publication statusPublished - 2016 Sep 2

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Autopsy
Pathology
Sclerosis
Tauopathies
Lewy Body Disease
Alzheimer Disease
Arteriolosclerosis
Cerebral Amyloid Angiopathy
Lewy Bodies
Cerebrovascular Disorders
Neurodegenerative Diseases
Hippocampus
Neuropathology
Prospective Studies
Guidelines
Brain
Population

Keywords

  • Aging
  • Amyloid-beta
  • Neuropathology
  • Supercentenarian
  • Tau
  • TDP-43

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Neuropathology of supercentenarians - four autopsy case studies. / Takao, Masaki; Hirose, Nobuyoshi; Arai, Yasumichi; Mihara, Ban; Mimura, Masaru.

In: Acta neuropathologica communications, Vol. 4, No. 1, 02.09.2016.

Research output: Contribution to journalArticle

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