Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation

Hiroyuki Nagashima, Tanel Mahlakõiv, Han Yu Shih, Fred P. Davis, Francoise Meylan, Yuefeng Huang, Oliver J. Harrison, Chen Yao, Yohei Mikami, Joseph F. Urban, Kathleen M. Caron, Yasmine Belkaid, Yuka Kanno, David Artis, John J. O'Shea

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Neuronal and immune systems coordinately orchestrate responses at mucosal barriers. Nagashima et al. applied scRNA-seq technology to track type 2 immune responses in worm infection, identifying neuropeptide CGRP as a factor that modulates inflammation. The study suggests that CGRP may be a useful target in type 2 inflammation.

Original languageEnglish
Pages (from-to)682-695.e6
JournalImmunity
Volume51
Issue number4
DOIs
Publication statusPublished - 2019 Oct 15
Externally publishedYes

Keywords

  • CGRP
  • cytokines
  • host defense
  • IL-33
  • immunoregulation
  • innate lymphoid cells
  • neuropeptides
  • Nippostrongylus brasiliensis
  • NMU
  • single-cell RNA-seq

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Nagashima, H., Mahlakõiv, T., Shih, H. Y., Davis, F. P., Meylan, F., Huang, Y., Harrison, O. J., Yao, C., Mikami, Y., Urban, J. F., Caron, K. M., Belkaid, Y., Kanno, Y., Artis, D., & O'Shea, J. J. (2019). Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation. Immunity, 51(4), 682-695.e6. https://doi.org/10.1016/j.immuni.2019.06.009