TY - JOUR
T1 - Neurophysiological biomarkers using transcranial magnetic stimulation in Alzheimer's disease and mild cognitive impairment
T2 - A systematic review and meta-analysis
AU - Mimura, Yu
AU - Nishida, Hana
AU - Nakajima, Shinichiro
AU - Tsugawa, Sakiko
AU - Morita, Shinji
AU - Yoshida, Kazunari
AU - Tarumi, Ryosuke
AU - Ogyu, Kamiyu
AU - Wada, Masataka
AU - Kurose, Shin
AU - Miyazaki, Takahiro
AU - Blumberger, Daniel M.
AU - Daskalakis, Zafiris J.
AU - Chen, Robert
AU - Mimura, Masaru
AU - Noda, Yoshihiro
N1 - Funding Information:
This work was supported by the Japan Society for the Promotion of Science and AMED (YN, SN, and MM). The funding agency did not contribute to the study design; in the data collection, analyses, and interpretation; in the writing of the manuscript; and in the decision to submit the manuscript for publication.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/2
Y1 - 2021/2
N2 - Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological tool that enables the investigation of cortical excitability in the human brain. Paired-pulse TMS paradigms include short- and long-interval intracortical inhibition (SICI/LICI), intracortical facilitation (ICF), and short-latency afferent inhibition (SAI), which can assess neurophysiological functions of GABAergic, glutamatergic, and cholinergic neural circuits, respectively. We conducted the first systematic review and meta-analysis to compare these TMS indices among patients with AD, mild cognitive impairment (MCI), and healthy controls (HC). Our meta-analyses indicated that RMT, SAI, SICI, and LICI were significantly lower in patients with AD, while ICF did not show a difference in patients with AD compared with HC. In patients with MCI, RMT and SAI were significantly lower than in HC. In conclusion, motor cortical excitability was increased, while cholinergic function was decreased in AD and MCI in comparison with HC and patients with AD had decreased GABAergic and glutamatergic functions compared with HC. Our results warrant further studies to differentiate AD, MCI, and HC, employing multimodal TMS neurophysiology.
AB - Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological tool that enables the investigation of cortical excitability in the human brain. Paired-pulse TMS paradigms include short- and long-interval intracortical inhibition (SICI/LICI), intracortical facilitation (ICF), and short-latency afferent inhibition (SAI), which can assess neurophysiological functions of GABAergic, glutamatergic, and cholinergic neural circuits, respectively. We conducted the first systematic review and meta-analysis to compare these TMS indices among patients with AD, mild cognitive impairment (MCI), and healthy controls (HC). Our meta-analyses indicated that RMT, SAI, SICI, and LICI were significantly lower in patients with AD, while ICF did not show a difference in patients with AD compared with HC. In patients with MCI, RMT and SAI were significantly lower than in HC. In conclusion, motor cortical excitability was increased, while cholinergic function was decreased in AD and MCI in comparison with HC and patients with AD had decreased GABAergic and glutamatergic functions compared with HC. Our results warrant further studies to differentiate AD, MCI, and HC, employing multimodal TMS neurophysiology.
KW - Alzheimer's disease
KW - Biomarker
KW - ICF
KW - LICI
KW - Mild cognitive impairment
KW - PAS
KW - Plasticity
KW - RMT
KW - SAI
KW - SICI
KW - TMS
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UR - http://www.scopus.com/inward/citedby.url?scp=85098470879&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2020.12.003
DO - 10.1016/j.neubiorev.2020.12.003
M3 - Review article
C2 - 33307047
AN - SCOPUS:85098470879
VL - 121
SP - 47
EP - 59
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
ER -
