Neurophysiological biomarkers using transcranial magnetic stimulation in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis

Yu Mimura, Hana Nishida, Shinichiro Nakajima, Sakiko Tsugawa, Shinji Morita, Kazunari Yoshida, Ryosuke Tarumi, Kamiyu Ogyu, Masataka Wada, Shin Kurose, Takahiro Miyazaki, Daniel M. Blumberger, Zafiris J. Daskalakis, Robert Chen, Masaru Mimura, Yoshihiro Noda

Research output: Contribution to journalReview articlepeer-review

Abstract

Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological tool that enables the investigation of cortical excitability in the human brain. Paired-pulse TMS paradigms include short- and long-interval intracortical inhibition (SICI/LICI), intracortical facilitation (ICF), and short-latency afferent inhibition (SAI), which can assess neurophysiological functions of GABAergic, glutamatergic, and cholinergic neural circuits, respectively. We conducted the first systematic review and meta-analysis to compare these TMS indices among patients with AD, mild cognitive impairment (MCI), and healthy controls (HC). Our meta-analyses indicated that RMT, SAI, SICI, and LICI were significantly lower in patients with AD, while ICF did not show a difference in patients with AD compared with HC. In patients with MCI, RMT and SAI were significantly lower than in HC. In conclusion, motor cortical excitability was increased, while cholinergic function was decreased in AD and MCI in comparison with HC and patients with AD had decreased GABAergic and glutamatergic functions compared with HC. Our results warrant further studies to differentiate AD, MCI, and HC, employing multimodal TMS neurophysiology.

Original languageEnglish
Pages (from-to)47-59
Number of pages13
JournalNeuroscience and Biobehavioral Reviews
Volume121
DOIs
Publication statusPublished - 2021 Feb

Keywords

  • Alzheimer's disease
  • Biomarker
  • ICF
  • LICI
  • Mild cognitive impairment
  • PAS
  • Plasticity
  • RMT
  • SAI
  • SICI
  • TMS

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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