Neuroprotection and neurosupplementation in ischaemic brain

T. Yamashita, K. Deguchi, K. Sawamoto, Hideyuki Okano, T. Kamiya, K. Abe

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Possible strategies for treating ischaemic stroke include: (i) neuroprotection (preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischaemia), and (ii) neurosupplementation (the repair of broken neuronal networks with newly born neurons in the chronic phase of cerebral ischaemia). In this paper, we review our recent progress in development of these distinct new strategies for treatment of damaged brain following a stroke. Firstly, we investigated the role of endogenous IL-6 (interleukin-6), which is one of the cytokines drastically induced by ischaemic stimuli, by administering IL-6RA (anti-IL-6 receptor monoclonal antibody) to mice.We found that endogenous IL-6 plays a critical role in neuroprotection and that its role may be mediated by STAT3 (signal transducer and activator of transcription-3) activation. Secondly, we studied the endogenous sources of the newly born neurons in the ischaemic striatum by region- and cell-type-specific cell labelling techniques. The results revealed that the SVZ (subventricular zone) is the principal source of the neuronal progenitors that migrate laterally towards the infarcted regions, and differentiate into newly born neurons. Finally, we developed a restorative stroke therapy with a bio-affinitive scaffold, which is an appropriate poly-porous structure releasing bioactive substances such as neurotrophic factor. This bio-affinitive scaffold is able to give an appropriate environment for newly born neurons. In future, we will combine these strategies to develop more effective therapies for treatment of strokes.

Original languageEnglish
Pages (from-to)1310-1312
Number of pages3
JournalBiochemical Society Transactions
Volume34
Issue number6
DOIs
Publication statusPublished - 2006

Fingerprint

Neurons
Brain
Stroke
Brain Ischemia
Scaffolds
Interleukin-6
Interleukin-6 Receptors
STAT3 Transcription Factor
Lateral Ventricles
Nerve Growth Factors
Labeling
Transcriptional Activation
Repair
Chemical activation
Monoclonal Antibodies
Neuroprotection
Apoptosis
Cytokines
Therapeutics

Keywords

  • Cerebral ischaemia
  • Interleukin-6
  • Neuroprotection
  • Neurotrophic factor
  • Scaffold
  • Subventricular zone

ASJC Scopus subject areas

  • Biochemistry

Cite this

Yamashita, T., Deguchi, K., Sawamoto, K., Okano, H., Kamiya, T., & Abe, K. (2006). Neuroprotection and neurosupplementation in ischaemic brain. Biochemical Society Transactions, 34(6), 1310-1312. https://doi.org/10.1042/BST0341310

Neuroprotection and neurosupplementation in ischaemic brain. / Yamashita, T.; Deguchi, K.; Sawamoto, K.; Okano, Hideyuki; Kamiya, T.; Abe, K.

In: Biochemical Society Transactions, Vol. 34, No. 6, 2006, p. 1310-1312.

Research output: Contribution to journalArticle

Yamashita, T, Deguchi, K, Sawamoto, K, Okano, H, Kamiya, T & Abe, K 2006, 'Neuroprotection and neurosupplementation in ischaemic brain', Biochemical Society Transactions, vol. 34, no. 6, pp. 1310-1312. https://doi.org/10.1042/BST0341310
Yamashita, T. ; Deguchi, K. ; Sawamoto, K. ; Okano, Hideyuki ; Kamiya, T. ; Abe, K. / Neuroprotection and neurosupplementation in ischaemic brain. In: Biochemical Society Transactions. 2006 ; Vol. 34, No. 6. pp. 1310-1312.
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