Neuroscience research using non-human primate models and genome editing

Noriyuki Kishi, Hideyuki Okano

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The common marmoset (Callithrix jacchus) is a small New World non-human primate indigenous to northeastern Brazil. This species has been attracting the attention of biomedical researchers and neuroscientists for its ease of handling and colony maintenance, unique behavioral characteristics, and several human-like traits, such as enriched social vocal communication and strong relationships between parents and offspring. Its high reproductive efficiency makes it particularly amenable for use in the development of transgenic and genome editing technologies in a non-human primate model. Our group has recently generated transgenic marmosets with germ line transmission, opening new avenues in primate research. In this chapter, we describe recent advances in neuroscience and disease research using common marmosets, and we outline potential uses of genome editing in non-human primates toward the development of knock-in/knock-out marmosets.

Original languageEnglish
Title of host publicationResearch and Perspectives in Neurosciences
PublisherSpringer Verlag
Pages73-81
Number of pages9
Edition9783319601915
DOIs
Publication statusPublished - 2017

Publication series

NameResearch and Perspectives in Neurosciences
Number9783319601915
ISSN (Print)0945-6082
ISSN (Electronic)2196-3096

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kishi, N., & Okano, H. (2017). Neuroscience research using non-human primate models and genome editing. In Research and Perspectives in Neurosciences (9783319601915 ed., pp. 73-81). (Research and Perspectives in Neurosciences; No. 9783319601915). Springer Verlag. https://doi.org/10.1007/978-3-319-60192-2_7