Neurospheroid array on a flexible substrate for cortical microstimulation

Keisuke Okita, Midori Kato-Negishi, Hiroaki Onoe, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This paper describes a centimeter-sized flexible multi-electrode array (MEA) integrated with a neuronal spheroid (neurospheroid) array. The MEA has a number of neurospheroids and can be applied to extensively curved surfaces (e.g., brain). We demonstrated that MEA successfully activated neurons within a neurospheroid on the microelectrode array. In addition, the MEA was used to activate 2D culture of cortical cells through the neurospheroids. These results mark an important step toward achieving minimally-invasive cortical microstimulation via neurospheroid-based stimulating systems.

Original languageEnglish
Title of host publicationProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Pages221-224
Number of pages4
DOIs
Publication statusPublished - 2013
Externally publishedYes
EventIEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013 - Taipei, Taiwan, Province of China
Duration: 2013 Jan 202013 Jan 24

Other

OtherIEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
CountryTaiwan, Province of China
CityTaipei
Period13/1/2013/1/24

Fingerprint

Electrodes
spheroids
Substrates
electrodes
Microelectrodes
Neurons
Brain
curved surfaces
neurons
brain
cells

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Okita, K., Kato-Negishi, M., Onoe, H., & Takeuchi, S. (2013). Neurospheroid array on a flexible substrate for cortical microstimulation. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 221-224). [6474217] https://doi.org/10.1109/MEMSYS.2013.6474217

Neurospheroid array on a flexible substrate for cortical microstimulation. / Okita, Keisuke; Kato-Negishi, Midori; Onoe, Hiroaki; Takeuchi, Shoji.

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2013. p. 221-224 6474217.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Okita, K, Kato-Negishi, M, Onoe, H & Takeuchi, S 2013, Neurospheroid array on a flexible substrate for cortical microstimulation. in Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)., 6474217, pp. 221-224, IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013, Taipei, Taiwan, Province of China, 13/1/20. https://doi.org/10.1109/MEMSYS.2013.6474217
Okita K, Kato-Negishi M, Onoe H, Takeuchi S. Neurospheroid array on a flexible substrate for cortical microstimulation. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2013. p. 221-224. 6474217 https://doi.org/10.1109/MEMSYS.2013.6474217
Okita, Keisuke ; Kato-Negishi, Midori ; Onoe, Hiroaki ; Takeuchi, Shoji. / Neurospheroid array on a flexible substrate for cortical microstimulation. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2013. pp. 221-224
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