Neurotrophic activity in cytokine-activated astrocytes

Kazunari Yoshida, Shigeo Toya

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Accumulating evidence indicates that various neurotrophic factors (NTFs) exist and function in the brain. In the mature mammalian brain, NTF expression is exclusively restricted to neurons. However, astrocytes activated by various cytokines, including fibroblast growth factor and interleukin-1̄, produce a significant amount of nerve growth factor (NGF) in vitro. Furthermore, non-NGF type NTF expression in astrocytes is also activated by the cytokines. The cytokines also enhance both release of ciliary neurotrophic factor from and expression of high-molecular weight basic fibroblast growth factor (FGF) in astrocytes. In the early phase following brain injury, cytokine-activated astrocytes rescue the damaged neurons via NTFs and other biologically active molecules.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalKeio Journal of Medicine
Volume46
Issue number2
Publication statusPublished - 1997 Jun

Fingerprint

Nerve Growth Factors
Astrocytes
Cytokines
Ciliary Neurotrophic Factor
Neurons
Fibroblast Growth Factor 1
Brain
Nerve Growth Factor
Fibroblast Growth Factor 2
Interleukin-1
Brain Injuries
Intercellular Signaling Peptides and Proteins
Molecular Weight

Keywords

  • Astrocyte
  • Cell adhesion molecule
  • Cytokine
  • Neurotrophic factor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neurotrophic activity in cytokine-activated astrocytes. / Yoshida, Kazunari; Toya, Shigeo.

In: Keio Journal of Medicine, Vol. 46, No. 2, 06.1997, p. 55-60.

Research output: Contribution to journalArticle

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