Neurotropic components from star anise (Illicium verum HOOK. fil.)

Tomonori Nakamura, Emi Okuyama, Mikio Yamazaki

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Abstract

Three new neurotropic sesquiterpenoids, veranisatins A, B and C, were isolated from star anise (Illicium verum HOOK. fil., Illiciaceae). Veranisatins showed convulsion and lethal toxicity in mice at a dose of 3 mg/kg (p.o.), and at lower doses they caused hypothermia. Veranisatin A and the related compound, anisatin, were tested for the other pharmacological activities such as locomotor activity and analgesic effect. Both compounds decreased the locomotion enhanced by methamphetamine at oral doses of 0.1 and 0.03 mg/kg, respectively, and demonstrated the analgesia on acetic acid- induced writhing and tail pressure pain at almost similar doses.

Original languageEnglish
Pages (from-to)1908-1914
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume44
Issue number10
Publication statusPublished - 1996 Oct
Externally publishedYes

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Keywords

  • analgesia
  • convulsion
  • hypothermia
  • Illicium verum
  • locomotor activity
  • veranisatin

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

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