Neurotropic components from star anise (Illicium verum HOOK. fil.)

Tomonori Nakamura, Emi Okuyama, Mikio Yamazaki

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Three new neurotropic sesquiterpenoids, veranisatins A, B and C, were isolated from star anise (Illicium verum HOOK. fil., Illiciaceae). Veranisatins showed convulsion and lethal toxicity in mice at a dose of 3 mg/kg (p.o.), and at lower doses they caused hypothermia. Veranisatin A and the related compound, anisatin, were tested for the other pharmacological activities such as locomotor activity and analgesic effect. Both compounds decreased the locomotion enhanced by methamphetamine at oral doses of 0.1 and 0.03 mg/kg, respectively, and demonstrated the analgesia on acetic acid- induced writhing and tail pressure pain at almost similar doses.

Original languageEnglish
Pages (from-to)1908-1914
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume44
Issue number10
Publication statusPublished - 1996 Oct
Externally publishedYes

Fingerprint

Illicium
Pimpinella
Locomotion
Stars
Hypothermia
Methamphetamine
Acetic Acid
Analgesia
Toxicity
Analgesics
Tail
Seizures
Pharmacology
Pressure
Pain
veranisatin A

Keywords

  • analgesia
  • convulsion
  • hypothermia
  • Illicium verum
  • locomotor activity
  • veranisatin

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Neurotropic components from star anise (Illicium verum HOOK. fil.). / Nakamura, Tomonori; Okuyama, Emi; Yamazaki, Mikio.

In: Chemical and Pharmaceutical Bulletin, Vol. 44, No. 10, 10.1996, p. 1908-1914.

Research output: Contribution to journalArticle

Nakamura, Tomonori ; Okuyama, Emi ; Yamazaki, Mikio. / Neurotropic components from star anise (Illicium verum HOOK. fil.). In: Chemical and Pharmaceutical Bulletin. 1996 ; Vol. 44, No. 10. pp. 1908-1914.
@article{ccec4544fc5a4ef3aac953f47806d08e,
title = "Neurotropic components from star anise (Illicium verum HOOK. fil.)",
abstract = "Three new neurotropic sesquiterpenoids, veranisatins A, B and C, were isolated from star anise (Illicium verum HOOK. fil., Illiciaceae). Veranisatins showed convulsion and lethal toxicity in mice at a dose of 3 mg/kg (p.o.), and at lower doses they caused hypothermia. Veranisatin A and the related compound, anisatin, were tested for the other pharmacological activities such as locomotor activity and analgesic effect. Both compounds decreased the locomotion enhanced by methamphetamine at oral doses of 0.1 and 0.03 mg/kg, respectively, and demonstrated the analgesia on acetic acid- induced writhing and tail pressure pain at almost similar doses.",
keywords = "analgesia, convulsion, hypothermia, Illicium verum, locomotor activity, veranisatin",
author = "Tomonori Nakamura and Emi Okuyama and Mikio Yamazaki",
year = "1996",
month = "10",
language = "English",
volume = "44",
pages = "1908--1914",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "Pharmaceutical Society of Japan",
number = "10",

}

TY - JOUR

T1 - Neurotropic components from star anise (Illicium verum HOOK. fil.)

AU - Nakamura, Tomonori

AU - Okuyama, Emi

AU - Yamazaki, Mikio

PY - 1996/10

Y1 - 1996/10

N2 - Three new neurotropic sesquiterpenoids, veranisatins A, B and C, were isolated from star anise (Illicium verum HOOK. fil., Illiciaceae). Veranisatins showed convulsion and lethal toxicity in mice at a dose of 3 mg/kg (p.o.), and at lower doses they caused hypothermia. Veranisatin A and the related compound, anisatin, were tested for the other pharmacological activities such as locomotor activity and analgesic effect. Both compounds decreased the locomotion enhanced by methamphetamine at oral doses of 0.1 and 0.03 mg/kg, respectively, and demonstrated the analgesia on acetic acid- induced writhing and tail pressure pain at almost similar doses.

AB - Three new neurotropic sesquiterpenoids, veranisatins A, B and C, were isolated from star anise (Illicium verum HOOK. fil., Illiciaceae). Veranisatins showed convulsion and lethal toxicity in mice at a dose of 3 mg/kg (p.o.), and at lower doses they caused hypothermia. Veranisatin A and the related compound, anisatin, were tested for the other pharmacological activities such as locomotor activity and analgesic effect. Both compounds decreased the locomotion enhanced by methamphetamine at oral doses of 0.1 and 0.03 mg/kg, respectively, and demonstrated the analgesia on acetic acid- induced writhing and tail pressure pain at almost similar doses.

KW - analgesia

KW - convulsion

KW - hypothermia

KW - Illicium verum

KW - locomotor activity

KW - veranisatin

UR - http://www.scopus.com/inward/record.url?scp=0029807583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029807583&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 1908

EP - 1914

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 10

ER -