Neurovascular crosstalk between interneurons and capillaries is required for vision

Yoshihiko Usui, Peter D. Westenskow, Toshihide Kurihara, Edith Aguilar, Susumu Sakimoto, Liliana P. Paris, Carli Wittgrove, Daniel Feitelberg, Mollie S H Friedlander, Stacey K. Moreno, Michael I. Dorrell, Martin Friedlander

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Functional interactions between neurons, vasculature, and glia within neurovascular units are critical for maintenance of the retina and other CNS tissues. For example, the architecture of the neurosensory retina is a highly organized structure with alternating layers of neurons and blood vessels that match the metabolic demand of neuronal activity with an appropriate supply of oxygen within perfused blood. Here, using murine genetic models and cell ablation strategies, we have demonstrated that a subset of retinal interneurons, the amacrine and horizontal cells, form neurovascular units with capillaries in 2 of the 3 retinal vascular plexuses. Moreover, we determined that these cells are required for generating and maintaining the intraretinal vasculature through precise regulation of hypoxia-inducible and proangiogenic factors, and that amacrine and horizontal cell dysfunction induces alterations to the intraretinal vasculature and substantial visual deficits. These findings demonstrate that specific retinal interneurons and the intraretinal vasculature are highly interdependent, and loss of either or both elicits profound effects on photoreceptor survival and function.

Original languageEnglish
Pages (from-to)2335-2346
Number of pages12
JournalJournal of Clinical Investigation
Volume125
Issue number6
DOIs
Publication statusPublished - 2015 Jun 1

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Amacrine Cells
Interneurons
Retina
Neurons
Retinal Vessels
Genetic Models
Neuroglia
Blood Vessels
Maintenance
Oxygen
Hypoxia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Usui, Y., Westenskow, P. D., Kurihara, T., Aguilar, E., Sakimoto, S., Paris, L. P., ... Friedlander, M. (2015). Neurovascular crosstalk between interneurons and capillaries is required for vision. Journal of Clinical Investigation, 125(6), 2335-2346. https://doi.org/10.1172/JCI80297

Neurovascular crosstalk between interneurons and capillaries is required for vision. / Usui, Yoshihiko; Westenskow, Peter D.; Kurihara, Toshihide; Aguilar, Edith; Sakimoto, Susumu; Paris, Liliana P.; Wittgrove, Carli; Feitelberg, Daniel; Friedlander, Mollie S H; Moreno, Stacey K.; Dorrell, Michael I.; Friedlander, Martin.

In: Journal of Clinical Investigation, Vol. 125, No. 6, 01.06.2015, p. 2335-2346.

Research output: Contribution to journalArticle

Usui, Y, Westenskow, PD, Kurihara, T, Aguilar, E, Sakimoto, S, Paris, LP, Wittgrove, C, Feitelberg, D, Friedlander, MSH, Moreno, SK, Dorrell, MI & Friedlander, M 2015, 'Neurovascular crosstalk between interneurons and capillaries is required for vision', Journal of Clinical Investigation, vol. 125, no. 6, pp. 2335-2346. https://doi.org/10.1172/JCI80297
Usui Y, Westenskow PD, Kurihara T, Aguilar E, Sakimoto S, Paris LP et al. Neurovascular crosstalk between interneurons and capillaries is required for vision. Journal of Clinical Investigation. 2015 Jun 1;125(6):2335-2346. https://doi.org/10.1172/JCI80297
Usui, Yoshihiko ; Westenskow, Peter D. ; Kurihara, Toshihide ; Aguilar, Edith ; Sakimoto, Susumu ; Paris, Liliana P. ; Wittgrove, Carli ; Feitelberg, Daniel ; Friedlander, Mollie S H ; Moreno, Stacey K. ; Dorrell, Michael I. ; Friedlander, Martin. / Neurovascular crosstalk between interneurons and capillaries is required for vision. In: Journal of Clinical Investigation. 2015 ; Vol. 125, No. 6. pp. 2335-2346.
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