Neutrophil elastase and elastin-derived peptides in BAL fluid and emphysematous changes on CT scans

T. Betsuyaku, M. Nishimura, A. Yoshioka, K. Takeyabu, K. Miyamoto, Y. Kawakami

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10 Citations (Scopus)

Abstract

We examined the relationship between neutrophil elastase, elatin- derived peptides in bronchoalveolar lavage (BAL) fluid, and the development of pulmonary emphysema. The level of neutrophil elastase was higher in asymptomatic current smokers with emphysematous changes on computed tomographic scans than in current smokers without emphysematous changes, and was found to be correlated with the level of elastin-derived peptides in BAL fluid. Subjects with high levels of neutrophil elastase in BAL fluid had faster annual declines in FEV1. We conclude that the level of neutrophil elastase in BAL fluid can be used to differentiate asymptomatic cigarette smokers who are at risk for pulmonary emphysema from those who are not.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalJapanese Journal of Thoracic Diseases
Volume34
Issue numberSUPPL.
Publication statusPublished - 1996 Dec 1

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Keywords

  • Bronchoalveolar lavage
  • Early diagnosis
  • Elastin- derived peptides
  • Neutrophil elastase
  • Pulmonary emphysema

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Betsuyaku, T., Nishimura, M., Yoshioka, A., Takeyabu, K., Miyamoto, K., & Kawakami, Y. (1996). Neutrophil elastase and elastin-derived peptides in BAL fluid and emphysematous changes on CT scans. Japanese Journal of Thoracic Diseases, 34(SUPPL.), 69-74.