New 2-(2-phenylethyl)chromone derivatives and inhibitors of phosphodiesterase (PDE) 3A from Agarwood

Takuji Sugiyama, Yuji Narukawa, Shunsuke Shibata, Ryo Masui, Fumiyuk Kiuchi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6, 8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6, 7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.

Original languageEnglish
Pages (from-to)795-797
Number of pages3
JournalNatural product communications
Volume11
Issue number6
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • 2-(2-Phenylethyl)chromone
  • Agarwood
  • Phosphodiesterase inhibitor

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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