New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood

Takuji Sugiyama, Yuuji Narukawa, Shunsuke Shibata, Ryo Masui, Fumiyuki Kiuchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6,8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6,7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.

Original languageEnglish
Pages (from-to)795-797
Number of pages3
JournalNatural Product Communications
Volume11
Issue number6
Publication statusPublished - 2016 Jun 1

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Type 3 Cyclic Nucleotide Phosphodiesterases
chemical derivatives
extracts
Chromones
inhibitory concentration 50
fractionation
Fluorescence Polarization
fluorescence
Inhibitory Concentration 50
2-(2-phenylethyl)chromone
methodology

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood. / Sugiyama, Takuji; Narukawa, Yuuji; Shibata, Shunsuke; Masui, Ryo; Kiuchi, Fumiyuki.

In: Natural Product Communications, Vol. 11, No. 6, 01.06.2016, p. 795-797.

Research output: Contribution to journalArticle

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