New analogs of the pyripyropene family of ACAT inhibitors via α-pyrone fragmentation and γ-acylation/cyclization

Rika Obata, Toshiaki Sunazuka, Zhiming Tian, Hiroshi Tomoda, Yoshihiro Harigaya, Satoshi Omura, Amos B. Smith

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The pyridine moiety of pyripyropene A was replaced with other aromatic and heteroaromatic substituents via α-pyrone degradation followed by dienolate γ-acylation and in situ cyclization.

Original languageEnglish
Pages (from-to)935-936
Number of pages2
JournalChemistry Letters
Issue number9
DOIs
Publication statusPublished - 1997 Jan 1

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ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Obata, R., Sunazuka, T., Tian, Z., Tomoda, H., Harigaya, Y., Omura, S., & Smith, A. B. (1997). New analogs of the pyripyropene family of ACAT inhibitors via α-pyrone fragmentation and γ-acylation/cyclization. Chemistry Letters, (9), 935-936. https://doi.org/10.1246/cl.1997.935