New analogs of the pyripyropene family of ACAT inhibitors via α-pyrone fragmentation and γ-acylation/cyclization

Rika Obata, Toshiaki Sunazuka, Zhiming Tian, Hiroshi Tomoda, Yoshihiro Harigaya, Satoshi Omura, Amos B. Smith

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The pyridine moiety of pyripyropene A was replaced with other aromatic and heteroaromatic substituents via α-pyrone degradation followed by dienolate γ-acylation and in situ cyclization.

Original languageEnglish
Pages (from-to)935-936
Number of pages2
JournalChemistry Letters
Issue number9
Publication statusPublished - 1997
Externally publishedYes

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Pyrones
Acylation
Cyclization
Degradation
pyripyropene A
pyridine

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Obata, R., Sunazuka, T., Tian, Z., Tomoda, H., Harigaya, Y., Omura, S., & Smith, A. B. (1997). New analogs of the pyripyropene family of ACAT inhibitors via α-pyrone fragmentation and γ-acylation/cyclization. Chemistry Letters, (9), 935-936.

New analogs of the pyripyropene family of ACAT inhibitors via α-pyrone fragmentation and γ-acylation/cyclization. / Obata, Rika; Sunazuka, Toshiaki; Tian, Zhiming; Tomoda, Hiroshi; Harigaya, Yoshihiro; Omura, Satoshi; Smith, Amos B.

In: Chemistry Letters, No. 9, 1997, p. 935-936.

Research output: Contribution to journalArticle

Obata, R, Sunazuka, T, Tian, Z, Tomoda, H, Harigaya, Y, Omura, S & Smith, AB 1997, 'New analogs of the pyripyropene family of ACAT inhibitors via α-pyrone fragmentation and γ-acylation/cyclization', Chemistry Letters, no. 9, pp. 935-936.
Obata, Rika ; Sunazuka, Toshiaki ; Tian, Zhiming ; Tomoda, Hiroshi ; Harigaya, Yoshihiro ; Omura, Satoshi ; Smith, Amos B. / New analogs of the pyripyropene family of ACAT inhibitors via α-pyrone fragmentation and γ-acylation/cyclization. In: Chemistry Letters. 1997 ; No. 9. pp. 935-936.
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AU - Smith, Amos B.

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