New and efficient catalysts for enantioselective borohydride reduction of ketones and imines

Takushi Nagata, Kiyoaki D. Sugi, Kiyotaka Yorozu, Tohru Yamada, Teruaki Mukaiyama

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Optically active aldiminato cobalt(II) complexes have been found to catalyze the enantioselective reduction of ketones with sodium borohydride affording the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities. The enantioselective borohydride reduction is also applicable to not only C=O bonds in aromatic ketones but also to C=N bonds in aromatic imines.

Original languageEnglish
Pages (from-to)47-57
Number of pages11
JournalCatalysis Surveys from Japan
Volume2
Issue number1
DOIs
Publication statusPublished - 1998 Jan 1

Keywords

  • Aromatic imine
  • Aromatic ketone
  • Borohydride
  • Cobalt
  • Enantioselective reduction
  • Primary amine
  • Secondary alcohol

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry

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