New and efficient catalysts for enantioselective borohydride reduction of ketones and imines

Takushi Nagata; Kiyoaki D. Sugi; Kiyotaka Yorozu; Tohru Yamada; Teruaki Mukaiyama

doi:10.1023/A:1019005803704

New and efficient catalysts for enantioselective borohydride reduction of ketones and imines

Takushi Nagata, Kiyoaki D. Sugi, Kiyotaka Yorozu, Tohru Yamada, Teruaki Mukaiyama

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Optically active aldiminato cobalt(II) complexes have been found to catalyze the enantioselective reduction of ketones with sodium borohydride affording the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities. The enantioselective borohydride reduction is also applicable to not only C=O bonds in aromatic ketones but also to C=N bonds in aromatic imines.

Original language	English
Pages (from-to)	47-57
Number of pages	11
Journal	Catalysis Surveys from Japan
Volume	2
Issue number	1
DOIs	https://doi.org/10.1023/A:1019005803704
Publication status	Published - 1998 Jan 1

Keywords

Aromatic imine
Aromatic ketone
Borohydride
Cobalt
Enantioselective reduction
Primary amine
Secondary alcohol

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry

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abstract = "Optically active aldiminato cobalt(II) complexes have been found to catalyze the enantioselective reduction of ketones with sodium borohydride affording the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities. The enantioselective borohydride reduction is also applicable to not only C=O bonds in aromatic ketones but also to C=N bonds in aromatic imines.",

keywords = "Aromatic imine, Aromatic ketone, Borohydride, Cobalt, Enantioselective reduction, Primary amine, Secondary alcohol",

author = "Takushi Nagata and Sugi, {Kiyoaki D.} and Kiyotaka Yorozu and Tohru Yamada and Teruaki Mukaiyama",

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T1 - New and efficient catalysts for enantioselective borohydride reduction of ketones and imines

AU - Nagata, Takushi

AU - Sugi, Kiyoaki D.

AU - Yorozu, Kiyotaka

AU - Yamada, Tohru

AU - Mukaiyama, Teruaki

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Optically active aldiminato cobalt(II) complexes have been found to catalyze the enantioselective reduction of ketones with sodium borohydride affording the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities. The enantioselective borohydride reduction is also applicable to not only C=O bonds in aromatic ketones but also to C=N bonds in aromatic imines.

AB - Optically active aldiminato cobalt(II) complexes have been found to catalyze the enantioselective reduction of ketones with sodium borohydride affording the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities. The enantioselective borohydride reduction is also applicable to not only C=O bonds in aromatic ketones but also to C=N bonds in aromatic imines.

KW - Aromatic imine

KW - Aromatic ketone

KW - Borohydride

KW - Cobalt

KW - Enantioselective reduction

KW - Primary amine

KW - Secondary alcohol

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New and efficient catalysts for enantioselective borohydride reduction of ketones and imines

Abstract

Keywords

ASJC Scopus subject areas

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