New aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer

Hiroyuki Murota, Yorihisa Kotobuki, Noriko Umegaki, Mamori Tani, Ichiro Katayama

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

It is considered that the mechanism in intractable cutaneous ulcer is deeply associated with prolongation at the inflammatory phase. Having evaluated the effects of Lipo-prostaglandin E1 (Lipo-PGE1) with indicators such as the reduction ratio of the ulcer area and the values of the inflammatory markers after dividing them into two groups of collagen diseases and non-collagen diseases and giving them Lipo-PGE1, we managed to obtain the result that Lipo-PGE1 administration could influence various inflammatory markers such as C-reactive protein (CRP), IL-6, and VEGF in addition to reduction of the ulcer region. It also suggested that Lipo-PGE1 has the effect of maintaining an appropriate balance of induction of inflammation and angiogenesis. Additionally, it revealed that Lipo-PGE1 controls the production of cytokines, which are associated with the growth of collagen diseases. From these results, it can be expected that Lipo-PGE1 will act favorably on intractable collagen diseases.

Original languageEnglish
Pages (from-to)1127-1135
Number of pages9
JournalRheumatology International
Volume28
Issue number11
DOIs
Publication statusPublished - 2008 Sep 1

Keywords

  • C-Reactive protein
  • IL-6
  • Lipo-prostaglandin E1
  • Skin ulcer
  • VEGF
  • sICAM-1

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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