New aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer

Hiroyuki Murota, Yorihisa Kotobuki, Noriko Umegaki, Mamori Tani, Ichiro Katayama

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

It is considered that the mechanism in intractable cutaneous ulcer is deeply associated with prolongation at the inflammatory phase. Having evaluated the effects of Lipo-prostaglandin E1 (Lipo-PGE1) with indicators such as the reduction ratio of the ulcer area and the values of the inflammatory markers after dividing them into two groups of collagen diseases and non-collagen diseases and giving them Lipo-PGE1, we managed to obtain the result that Lipo-PGE1 administration could influence various inflammatory markers such as C-reactive protein (CRP), IL-6, and VEGF in addition to reduction of the ulcer region. It also suggested that Lipo-PGE1 has the effect of maintaining an appropriate balance of induction of inflammation and angiogenesis. Additionally, it revealed that Lipo-PGE1 controls the production of cytokines, which are associated with the growth of collagen diseases. From these results, it can be expected that Lipo-PGE1 will act favorably on intractable collagen diseases.

Original languageEnglish
Pages (from-to)1127-1135
Number of pages9
JournalRheumatology International
Volume28
Issue number11
DOIs
Publication statusPublished - 2008 Sep

Keywords

  • C-Reactive protein
  • IL-6
  • Lipo-prostaglandin E1
  • Skin ulcer
  • VEGF
  • sICAM-1

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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