Abstract
Regulation of cardiac ion channels by sex hormones accounts for gender differences in susceptibility to arrhythmias associated with QT prolongation (TdP). Women are more prone to develop TdP than men with either congenital or acquired long-QT syndrome. The risk of drug- induced TdP varies during the menstrual cycle, suggesting that dynamic changes in levels of ovarian steroids, estradiol and progesterone, have cyclical effects on cardiac repolarization. Although increasing evidence suggests that the mechanism of this involves effects of female hormones on cardiac repolarization, it has not been completely clarified. In addition to well- characterized transcriptional regulation of cardiac ion channels and their modifiers through nuclear hormone receptors, we recently reported that physiological levels of female hormones modify functions of cardiac ion channels in mammalian hearts. In this review, we introduce our recent findings showing that physiological levels of the two ovarian steroids have opposite effects on cardiac repolarization. These findings may explain the dynamic changes in risk of arrhythmia in women during the menstrual cycle and around delivery, and they provide clues to avoiding potentially lethal arrhythmias associated with QT prolongation.
| Original language | English |
|---|---|
| Pages (from-to) | 334-340 |
| Number of pages | 7 |
| Journal | Journal of Pharmacological Sciences |
| Volume | 109 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Arrhythmia
- Cardiac disease
- Cardiac ion channel
- Gender difference
- Menstrual cycle
- Sex hormone
ASJC Scopus subject areas
- Pharmacology
- Molecular Medicine
Cite this
New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles : Acute effects of female hormones on cardiac ion channels and cardiac repolarization. / Kurokawa, Junko; Suzuki, Takeshi; Furukawa, Tetsushi.
In: Journal of Pharmacological Sciences, Vol. 109, No. 3, 2009, p. 334-340.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles
T2 - Acute effects of female hormones on cardiac ion channels and cardiac repolarization
AU - Kurokawa, Junko
AU - Suzuki, Takeshi
AU - Furukawa, Tetsushi
PY - 2009
Y1 - 2009
N2 - Regulation of cardiac ion channels by sex hormones accounts for gender differences in susceptibility to arrhythmias associated with QT prolongation (TdP). Women are more prone to develop TdP than men with either congenital or acquired long-QT syndrome. The risk of drug- induced TdP varies during the menstrual cycle, suggesting that dynamic changes in levels of ovarian steroids, estradiol and progesterone, have cyclical effects on cardiac repolarization. Although increasing evidence suggests that the mechanism of this involves effects of female hormones on cardiac repolarization, it has not been completely clarified. In addition to well- characterized transcriptional regulation of cardiac ion channels and their modifiers through nuclear hormone receptors, we recently reported that physiological levels of female hormones modify functions of cardiac ion channels in mammalian hearts. In this review, we introduce our recent findings showing that physiological levels of the two ovarian steroids have opposite effects on cardiac repolarization. These findings may explain the dynamic changes in risk of arrhythmia in women during the menstrual cycle and around delivery, and they provide clues to avoiding potentially lethal arrhythmias associated with QT prolongation.
AB - Regulation of cardiac ion channels by sex hormones accounts for gender differences in susceptibility to arrhythmias associated with QT prolongation (TdP). Women are more prone to develop TdP than men with either congenital or acquired long-QT syndrome. The risk of drug- induced TdP varies during the menstrual cycle, suggesting that dynamic changes in levels of ovarian steroids, estradiol and progesterone, have cyclical effects on cardiac repolarization. Although increasing evidence suggests that the mechanism of this involves effects of female hormones on cardiac repolarization, it has not been completely clarified. In addition to well- characterized transcriptional regulation of cardiac ion channels and their modifiers through nuclear hormone receptors, we recently reported that physiological levels of female hormones modify functions of cardiac ion channels in mammalian hearts. In this review, we introduce our recent findings showing that physiological levels of the two ovarian steroids have opposite effects on cardiac repolarization. These findings may explain the dynamic changes in risk of arrhythmia in women during the menstrual cycle and around delivery, and they provide clues to avoiding potentially lethal arrhythmias associated with QT prolongation.
KW - Arrhythmia
KW - Cardiac disease
KW - Cardiac ion channel
KW - Gender difference
KW - Menstrual cycle
KW - Sex hormone
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U2 - 10.1254/jphs.08R23FM
DO - 10.1254/jphs.08R23FM
M3 - Article
C2 - 19270425
AN - SCOPUS:67249120468
VL - 109
SP - 334
EP - 340
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 3
ER -