TY - JOUR
T1 - New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome
AU - Ishizaka, Akitoshi
AU - Watanabe, Masazumi
AU - Yamashita, Tetsuji
AU - Ogawa, Yasuyo
AU - Koh, Hidefumi
AU - Hasegawa, Naoki
AU - Nakamura, Hidetoshi
AU - Asano, Koichiro
AU - Yamaguchi, Kazuhiro
AU - Kotani, Mariko
AU - Kotani, Toru
AU - Morisaki, Hiroshi
AU - Takeda, Junzo
AU - Kobayashi, Koichi
AU - Ogawa, Satoshi
PY - 2001
Y1 - 2001
N2 - Objective: A noninvasive bronchoscopic microsampling (BMS) probe was developed to sample biochemical constituents of the epithelial lining fluid in small airways. Design: Observational, controlled study. Setting: Intensive care unit of academic medical center. Patients and Procedure: BMS was applied in a control group of seven patients who had hemoptysis or small solitary peripheral nodules but no hypoxemia or other signs of acute inflammation and in four patients with acute respiratory distress syndrome (ARDS), to test whether BMS can ascertain the presence of acute pulmonary inflammation without complications. Measurements and Results: Complications, including a significant decrease in arterial oxygen saturation, were observed neither during nor after BUS. In the ARDS group, albumin, lactate dehydrogenase, interleukin-6, basic fibroblast growth factor, and neutrophil elastase concentrations in epithelial lining fluid were significantly higher (p < .0001, p = .012, p < .0001, p < .0001, and p < .0001, respectively) than in the control group. Serial BMS was safely performed in one patient with ARDS, allowing us to observe a correlation between changes in the concentration of inflammation-related biochemical markers and clinical course of the disease. Conclusions: These results suggest that BMS is safe and useful to monitor pulmonary biochemical events in ARDS.
AB - Objective: A noninvasive bronchoscopic microsampling (BMS) probe was developed to sample biochemical constituents of the epithelial lining fluid in small airways. Design: Observational, controlled study. Setting: Intensive care unit of academic medical center. Patients and Procedure: BMS was applied in a control group of seven patients who had hemoptysis or small solitary peripheral nodules but no hypoxemia or other signs of acute inflammation and in four patients with acute respiratory distress syndrome (ARDS), to test whether BMS can ascertain the presence of acute pulmonary inflammation without complications. Measurements and Results: Complications, including a significant decrease in arterial oxygen saturation, were observed neither during nor after BUS. In the ARDS group, albumin, lactate dehydrogenase, interleukin-6, basic fibroblast growth factor, and neutrophil elastase concentrations in epithelial lining fluid were significantly higher (p < .0001, p = .012, p < .0001, p < .0001, and p < .0001, respectively) than in the control group. Serial BMS was safely performed in one patient with ARDS, allowing us to observe a correlation between changes in the concentration of inflammation-related biochemical markers and clinical course of the disease. Conclusions: These results suggest that BMS is safe and useful to monitor pulmonary biochemical events in ARDS.
KW - Acute inflammatory lung injury
KW - Acute respiratory distress syndrome
KW - Bronchoalveolar lavage
KW - Bronchoscopic microsampling
KW - Epithelial lining fluid
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U2 - 10.1097/00003246-200104000-00043
DO - 10.1097/00003246-200104000-00043
M3 - Article
C2 - 11373491
AN - SCOPUS:0035046339
VL - 29
SP - 896
EP - 898
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - 4
ER -