New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT

Hideo Takakura; Ryosuke Kojima; Mako Kamiya; Eiji Kobayashi; Toru Komatsu; Tasuku Ueno; Takuya Terai; Kenjiro Hanaoka; Tetsuo Nagano; Yasuteru Urano

doi:10.1021/ja511014w

New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT

Hideo Takakura, Ryosuke Kojima, Mako Kamiya, Eiji Kobayashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano, Yasuteru Urano

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Bioluminescence imaging (BLI) has advantages for investigating biological phenomena in deep tissues of living animals, but few design strategies are available for functional bioluminescent substrates. We propose a new design strategy (designated as bioluminescent enzyme-induced electron transfer: BioLeT) for luciferin-based bioluminescence probes. Luminescence measurements of a series of aminoluciferin derivatives confirmed that bioluminescence can be controlled by means of BioLeT. Based on this concept, we developed bioluminescence probes for nitric oxide that enabled quantitative and sensitive detection even in vivo. Our design strategy should be applicable to develop a wide range of practically useful bioluminogenic probes.

Original language	English
Pages (from-to)	4010-4013
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	137
Issue number	12
DOIs	https://doi.org/10.1021/ja511014w
Publication status	Published - 2015 Apr 1
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja511014w

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title = "New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT",

abstract = "Bioluminescence imaging (BLI) has advantages for investigating biological phenomena in deep tissues of living animals, but few design strategies are available for functional bioluminescent substrates. We propose a new design strategy (designated as bioluminescent enzyme-induced electron transfer: BioLeT) for luciferin-based bioluminescence probes. Luminescence measurements of a series of aminoluciferin derivatives confirmed that bioluminescence can be controlled by means of BioLeT. Based on this concept, we developed bioluminescence probes for nitric oxide that enabled quantitative and sensitive detection even in vivo. Our design strategy should be applicable to develop a wide range of practically useful bioluminogenic probes.",

author = "Hideo Takakura and Ryosuke Kojima and Mako Kamiya and Eiji Kobayashi and Toru Komatsu and Tasuku Ueno and Takuya Terai and Kenjiro Hanaoka and Tetsuo Nagano and Yasuteru Urano",

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T1 - New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer

T2 - BioLeT

AU - Takakura, Hideo

AU - Kojima, Ryosuke

AU - Kamiya, Mako

AU - Kobayashi, Eiji

AU - Komatsu, Toru

AU - Ueno, Tasuku

AU - Terai, Takuya

AU - Hanaoka, Kenjiro

AU - Nagano, Tetsuo

AU - Urano, Yasuteru

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Bioluminescence imaging (BLI) has advantages for investigating biological phenomena in deep tissues of living animals, but few design strategies are available for functional bioluminescent substrates. We propose a new design strategy (designated as bioluminescent enzyme-induced electron transfer: BioLeT) for luciferin-based bioluminescence probes. Luminescence measurements of a series of aminoluciferin derivatives confirmed that bioluminescence can be controlled by means of BioLeT. Based on this concept, we developed bioluminescence probes for nitric oxide that enabled quantitative and sensitive detection even in vivo. Our design strategy should be applicable to develop a wide range of practically useful bioluminogenic probes.

AB - Bioluminescence imaging (BLI) has advantages for investigating biological phenomena in deep tissues of living animals, but few design strategies are available for functional bioluminescent substrates. We propose a new design strategy (designated as bioluminescent enzyme-induced electron transfer: BioLeT) for luciferin-based bioluminescence probes. Luminescence measurements of a series of aminoluciferin derivatives confirmed that bioluminescence can be controlled by means of BioLeT. Based on this concept, we developed bioluminescence probes for nitric oxide that enabled quantitative and sensitive detection even in vivo. Our design strategy should be applicable to develop a wide range of practically useful bioluminogenic probes.

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New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT

Abstract

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