New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L

Yuji Narukawa; Akiko Niimura; Hitomi Noguchi; Hiroomi Tamura; Fumiyuki Kiuchi

doi:10.1007/s11418-013-0781-0

New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L

Yuji Narukawa, Akiko Niimura, Hitomi Noguchi, Hiroomi Tamura, Fumiyuki Kiuchi

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Four new diterpenoids (1-4), along with eight known diterpenoids (5-12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.). The structures of the compounds were determined by spectroscopic methods. Among the isolated compounds, compounds 2, 3, 8, 9 and 10 showed inhibitory activity against human liver cytosol estrogen sulfotransferase (E-ST), which plays a key role in the maintenance of cellular estrogen levels. Compound 2 showed the strongest activity with an IC ₅₀ value of 7.9 μM, which is comparable to the activity of the positive control, meclofenamic acid (IC₅₀ 5.4 μM).

Original language	English
Pages (from-to)	125-131
Number of pages	7
Journal	Journal of Natural Medicines
Volume	68
Issue number	1
DOIs	https://doi.org/10.1007/s11418-013-0781-0
Publication status	Published - 2014 Jan
Externally published	Yes

Keywords

Estrogen sulfotransferase
Inhibitor
Labdane type diterpenoids
Leonurus sibiricus

ASJC Scopus subject areas

Molecular Medicine

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10.1007/s11418-013-0781-0

Cite this

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title = "New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L",

abstract = "Four new diterpenoids (1-4), along with eight known diterpenoids (5-12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.). The structures of the compounds were determined by spectroscopic methods. Among the isolated compounds, compounds 2, 3, 8, 9 and 10 showed inhibitory activity against human liver cytosol estrogen sulfotransferase (E-ST), which plays a key role in the maintenance of cellular estrogen levels. Compound 2 showed the strongest activity with an IC 50 value of 7.9 μM, which is comparable to the activity of the positive control, meclofenamic acid (IC50 5.4 μM).",

keywords = "Estrogen sulfotransferase, Inhibitor, Labdane type diterpenoids, Leonurus sibiricus",

author = "Yuji Narukawa and Akiko Niimura and Hitomi Noguchi and Hiroomi Tamura and Fumiyuki Kiuchi",

note = "Funding Information: Acknowledgments This work was supported in part by MEXT-supported program for the Strategic Research Foundation at Private Universities and Keio Gijuku Academic Development Funds.",

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doi = "10.1007/s11418-013-0781-0",

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AU - Narukawa, Yuji

AU - Niimura, Akiko

AU - Noguchi, Hitomi

AU - Tamura, Hiroomi

AU - Kiuchi, Fumiyuki

N1 - Funding Information: Acknowledgments This work was supported in part by MEXT-supported program for the Strategic Research Foundation at Private Universities and Keio Gijuku Academic Development Funds.

PY - 2014/1

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AB - Four new diterpenoids (1-4), along with eight known diterpenoids (5-12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.). The structures of the compounds were determined by spectroscopic methods. Among the isolated compounds, compounds 2, 3, 8, 9 and 10 showed inhibitory activity against human liver cytosol estrogen sulfotransferase (E-ST), which plays a key role in the maintenance of cellular estrogen levels. Compound 2 showed the strongest activity with an IC 50 value of 7.9 μM, which is comparable to the activity of the positive control, meclofenamic acid (IC50 5.4 μM).

KW - Estrogen sulfotransferase

KW - Inhibitor

KW - Labdane type diterpenoids

KW - Leonurus sibiricus

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New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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