New flavanol dimers from the bark of celtis tetrandra and their TRAIL Resistance-Overcoming activity

Prapairat Seephonkai, Ryusho Ishikawa, Midori A. Arai, Thaworn Kowithayakorn, Takashi Koyano, Masami Ishibashi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In the courses of our search for bioactive natural products on TRAIL resistance-overcoming activity, the active EtOAc extract from the bark of Celtis tetrandra was chemically investigated. The fractionation of the extract resulted in the isolation of flavanols; (+)-afzelechin (1), (-)-epiafzelechin (2), (-)-catechin (3), and two new flavanol dimers; (-)-epiafzelechin-(4α8)-(-)-catechin (4) and (-)-epiafzelechin-(4α 8)-(-)-epicatechin (5). All isolated compounds 1-5 were tested for their TRAIL resistance-overcoming activity against AGS cells at the concentrations from 5-20 µM. It is likely that the flavanol dimers 4 and 5 exhibited weak activity in the range of the concentration of 10-20 µM as compared with the standard.

Original languageEnglish
Pages (from-to)427-430
Number of pages4
JournalNatural product communications
Volume13
Issue number4
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Keywords

  • (-)-Catechin
  • Celtis tetrandra
  • Flavanol dimers
  • Flavanols
  • TRAIL resistance-overcoming activity.

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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  • Cite this

    Seephonkai, P., Ishikawa, R., Arai, M. A., Kowithayakorn, T., Koyano, T., & Ishibashi, M. (2018). New flavanol dimers from the bark of celtis tetrandra and their TRAIL Resistance-Overcoming activity. Natural product communications, 13(4), 427-430.