New Grading System for the Evaluation of Chronic Ocular Manifestations in Patients with Stevens-Johnson Syndrome

Chie Sotozono, Leonard P K Ang, Noriko Koizumi, Hisayo Higashihara, Mayumi Ueta, Tsutomu Inatomi, Norihiko Yokoi, Minako Kaido, Murat Dogru, Jun Shimazaki, Kazuo Tsubota, Masakazu Yamada, Shigeru Kinoshita

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Purpose: To evaluate and grade the extent and severity of chronic ocular manifestations in Stevens-Johnson syndrome (SJS). Design: Prospective multicenter case series. Participants: We enrolled 73 patients (138 eyes) with SJS seen between April 2003 and March 2005 at 3 tertiary referral centers. Methods: Patients with a confirmed history of SJS and chronic ocular complications that persisted for at least 1 year from the onset of SJS were included. Their detailed medical history and ophthalmic examination results were recorded on an itemized data collection form. Complications were categorized as corneal, conjunctival, and eyelid complications, and 13 components were evaluated and graded on a scale from 0 to 3 according to their severity. Main Outcome Measures: These were broadly classified as corneal (superficial punctate keratopathy, epithelial defect, loss of the palisades of Vogt, conjunctivalization, neovascularization, opacification, keratinization), conjunctival (hyperemia, symblepharon formation), and eyelid (trichiasis, mucocutaneous junction involvement, meibomian gland involvement, punctal damage) complications. Results: The most severely affected complication components were loss of the palisades of Vogt (114 eyes; 82.6%) and meibomian gland involvement (102 eyes; 73.9%). Visual acuity in 74 of the 138 eyes (53.6%) was worse than 20/200. The severity of corneal, conjunctival, and eyelid complications was significantly correlated with visual loss. All 13 complications were correlated significantly with logarithm of the minimum angle of resolution (logMAR) visual acuity; the correlation coefficient (R) ranged from 0.359 to 0.810 (P<0.0001); for corneal epithelial defects, R was 0.169 (P = 0.0473). Eyes with a higher total score for the 3 complication categories had poorer vision (R = 0.806; P<0.0001). Multivariate regression analysis showed that corneal neovascularization, opacification, keratinization, and cataracts significantly affected logMAR visual acuity (P<0.0001, P<0.0001, P = 0.0142, P = 0.0375, respectively). Conclusions: The authors describe a new method for grading the extent and severity of ocular involvement in patients with SJS and demonstrate that the severity of ocular involvement is correlated significantly with the final visual outcome. This new grading system provides a more objective method for evaluating SJS patients and may be adapted for use in other cicatricial ocular surface diseases.

Original languageEnglish
Pages (from-to)1294-1302
Number of pages9
JournalOphthalmology
Volume114
Issue number7
DOIs
Publication statusPublished - 2007 Jul

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Eye Manifestations
Stevens-Johnson Syndrome
Eyelids
Meibomian Glands
Visual Acuity
Trichiasis
Corneal Neovascularization
Eye Diseases
Hyperemia
Tertiary Care Centers
Cataract
Multivariate Analysis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Sotozono, C., Ang, L. P. K., Koizumi, N., Higashihara, H., Ueta, M., Inatomi, T., ... Kinoshita, S. (2007). New Grading System for the Evaluation of Chronic Ocular Manifestations in Patients with Stevens-Johnson Syndrome. Ophthalmology, 114(7), 1294-1302. https://doi.org/10.1016/j.ophtha.2006.10.029

New Grading System for the Evaluation of Chronic Ocular Manifestations in Patients with Stevens-Johnson Syndrome. / Sotozono, Chie; Ang, Leonard P K; Koizumi, Noriko; Higashihara, Hisayo; Ueta, Mayumi; Inatomi, Tsutomu; Yokoi, Norihiko; Kaido, Minako; Dogru, Murat; Shimazaki, Jun; Tsubota, Kazuo; Yamada, Masakazu; Kinoshita, Shigeru.

In: Ophthalmology, Vol. 114, No. 7, 07.2007, p. 1294-1302.

Research output: Contribution to journalArticle

Sotozono, C, Ang, LPK, Koizumi, N, Higashihara, H, Ueta, M, Inatomi, T, Yokoi, N, Kaido, M, Dogru, M, Shimazaki, J, Tsubota, K, Yamada, M & Kinoshita, S 2007, 'New Grading System for the Evaluation of Chronic Ocular Manifestations in Patients with Stevens-Johnson Syndrome', Ophthalmology, vol. 114, no. 7, pp. 1294-1302. https://doi.org/10.1016/j.ophtha.2006.10.029
Sotozono, Chie ; Ang, Leonard P K ; Koizumi, Noriko ; Higashihara, Hisayo ; Ueta, Mayumi ; Inatomi, Tsutomu ; Yokoi, Norihiko ; Kaido, Minako ; Dogru, Murat ; Shimazaki, Jun ; Tsubota, Kazuo ; Yamada, Masakazu ; Kinoshita, Shigeru. / New Grading System for the Evaluation of Chronic Ocular Manifestations in Patients with Stevens-Johnson Syndrome. In: Ophthalmology. 2007 ; Vol. 114, No. 7. pp. 1294-1302.
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abstract = "Purpose: To evaluate and grade the extent and severity of chronic ocular manifestations in Stevens-Johnson syndrome (SJS). Design: Prospective multicenter case series. Participants: We enrolled 73 patients (138 eyes) with SJS seen between April 2003 and March 2005 at 3 tertiary referral centers. Methods: Patients with a confirmed history of SJS and chronic ocular complications that persisted for at least 1 year from the onset of SJS were included. Their detailed medical history and ophthalmic examination results were recorded on an itemized data collection form. Complications were categorized as corneal, conjunctival, and eyelid complications, and 13 components were evaluated and graded on a scale from 0 to 3 according to their severity. Main Outcome Measures: These were broadly classified as corneal (superficial punctate keratopathy, epithelial defect, loss of the palisades of Vogt, conjunctivalization, neovascularization, opacification, keratinization), conjunctival (hyperemia, symblepharon formation), and eyelid (trichiasis, mucocutaneous junction involvement, meibomian gland involvement, punctal damage) complications. Results: The most severely affected complication components were loss of the palisades of Vogt (114 eyes; 82.6{\%}) and meibomian gland involvement (102 eyes; 73.9{\%}). Visual acuity in 74 of the 138 eyes (53.6{\%}) was worse than 20/200. The severity of corneal, conjunctival, and eyelid complications was significantly correlated with visual loss. All 13 complications were correlated significantly with logarithm of the minimum angle of resolution (logMAR) visual acuity; the correlation coefficient (R) ranged from 0.359 to 0.810 (P<0.0001); for corneal epithelial defects, R was 0.169 (P = 0.0473). Eyes with a higher total score for the 3 complication categories had poorer vision (R = 0.806; P<0.0001). Multivariate regression analysis showed that corneal neovascularization, opacification, keratinization, and cataracts significantly affected logMAR visual acuity (P<0.0001, P<0.0001, P = 0.0142, P = 0.0375, respectively). Conclusions: The authors describe a new method for grading the extent and severity of ocular involvement in patients with SJS and demonstrate that the severity of ocular involvement is correlated significantly with the final visual outcome. This new grading system provides a more objective method for evaluating SJS patients and may be adapted for use in other cicatricial ocular surface diseases.",
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AU - Ang, Leonard P K

AU - Koizumi, Noriko

AU - Higashihara, Hisayo

AU - Ueta, Mayumi

AU - Inatomi, Tsutomu

AU - Yokoi, Norihiko

AU - Kaido, Minako

AU - Dogru, Murat

AU - Shimazaki, Jun

AU - Tsubota, Kazuo

AU - Yamada, Masakazu

AU - Kinoshita, Shigeru

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N2 - Purpose: To evaluate and grade the extent and severity of chronic ocular manifestations in Stevens-Johnson syndrome (SJS). Design: Prospective multicenter case series. Participants: We enrolled 73 patients (138 eyes) with SJS seen between April 2003 and March 2005 at 3 tertiary referral centers. Methods: Patients with a confirmed history of SJS and chronic ocular complications that persisted for at least 1 year from the onset of SJS were included. Their detailed medical history and ophthalmic examination results were recorded on an itemized data collection form. Complications were categorized as corneal, conjunctival, and eyelid complications, and 13 components were evaluated and graded on a scale from 0 to 3 according to their severity. Main Outcome Measures: These were broadly classified as corneal (superficial punctate keratopathy, epithelial defect, loss of the palisades of Vogt, conjunctivalization, neovascularization, opacification, keratinization), conjunctival (hyperemia, symblepharon formation), and eyelid (trichiasis, mucocutaneous junction involvement, meibomian gland involvement, punctal damage) complications. Results: The most severely affected complication components were loss of the palisades of Vogt (114 eyes; 82.6%) and meibomian gland involvement (102 eyes; 73.9%). Visual acuity in 74 of the 138 eyes (53.6%) was worse than 20/200. The severity of corneal, conjunctival, and eyelid complications was significantly correlated with visual loss. All 13 complications were correlated significantly with logarithm of the minimum angle of resolution (logMAR) visual acuity; the correlation coefficient (R) ranged from 0.359 to 0.810 (P<0.0001); for corneal epithelial defects, R was 0.169 (P = 0.0473). Eyes with a higher total score for the 3 complication categories had poorer vision (R = 0.806; P<0.0001). Multivariate regression analysis showed that corneal neovascularization, opacification, keratinization, and cataracts significantly affected logMAR visual acuity (P<0.0001, P<0.0001, P = 0.0142, P = 0.0375, respectively). Conclusions: The authors describe a new method for grading the extent and severity of ocular involvement in patients with SJS and demonstrate that the severity of ocular involvement is correlated significantly with the final visual outcome. This new grading system provides a more objective method for evaluating SJS patients and may be adapted for use in other cicatricial ocular surface diseases.

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