New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi

Nahoko Uchiyama, Fumiyuki Kiuchi, Michiho Ito, Gisho Honda, Yoshio Takeda, Olimjon K. Khodzhimatov, Ozodbek A. Ashurmetov

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 μM.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalJournal of Natural Products
Volume66
Issue number1
DOIs
Publication statusPublished - 2003 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Uchiyama, N., Kiuchi, F., Ito, M., Honda, G., Takeda, Y., Khodzhimatov, O. K., & Ashurmetov, O. A. (2003). New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi. Journal of Natural Products, 66(1), 128-131. https://doi.org/10.1021/np020308z