Abstract
Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 μM.
| Original language | English |
|---|---|
| Pages (from-to) | 128-131 |
| Number of pages | 4 |
| Journal | Journal of Natural Products |
| Volume | 66 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2003 Jan 1 |
| Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Cite this
Uchiyama, N., Kiuchi, F., Ito, M., Honda, G., Takeda, Y., Khodzhimatov, O. K., & Ashurmetov, O. A. (2003). New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi. Journal of Natural Products, 66(1), 128-131. https://doi.org/10.1021/np020308z