New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi

Nahoko Uchiyama, Fumiyuki Kiuchi, Michiho Ito, Gisho Honda, Yoshio Takeda, Olimjon K. Khodzhimatov, Ozodbek A. Ashurmetov

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 μM.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalJournal of Natural Products
Volume66
Issue number1
DOIs
Publication statusPublished - 2003 Jan 1
Externally publishedYes

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Dracocephalum
Diterpenes
diterpenoids
Chagas disease
Chagas Disease
Trypanosoma cruzi
spectral analysis
komaroviquinone

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Uchiyama, N., Kiuchi, F., Ito, M., Honda, G., Takeda, Y., Khodzhimatov, O. K., & Ashurmetov, O. A. (2003). New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi. Journal of Natural Products, 66(1), 128-131. https://doi.org/10.1021/np020308z

New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi. / Uchiyama, Nahoko; Kiuchi, Fumiyuki; Ito, Michiho; Honda, Gisho; Takeda, Yoshio; Khodzhimatov, Olimjon K.; Ashurmetov, Ozodbek A.

In: Journal of Natural Products, Vol. 66, No. 1, 01.01.2003, p. 128-131.

Research output: Contribution to journalArticle

Uchiyama, N, Kiuchi, F, Ito, M, Honda, G, Takeda, Y, Khodzhimatov, OK & Ashurmetov, OA 2003, 'New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi', Journal of Natural Products, vol. 66, no. 1, pp. 128-131. https://doi.org/10.1021/np020308z
Uchiyama, Nahoko ; Kiuchi, Fumiyuki ; Ito, Michiho ; Honda, Gisho ; Takeda, Yoshio ; Khodzhimatov, Olimjon K. ; Ashurmetov, Ozodbek A. / New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi. In: Journal of Natural Products. 2003 ; Vol. 66, No. 1. pp. 128-131.
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