New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi

Nahoko Uchiyama; Fumiyuki Kiuchi; Michiho Ito; Gisho Honda; Yoshio Takeda; Olimjon K. Khodzhimatov; Ozodbek A. Ashurmetov

doi:10.1021/np020308z

New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi

Nahoko Uchiyama, Fumiyuki Kiuchi, Michiho Ito, Gisho Honda, Yoshio Takeda, Olimjon K. Khodzhimatov, Ozodbek A. Ashurmetov

Research output: Contribution to journal › Article

78 Citations (Scopus)

Abstract

Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 μM.

Original language	English
Pages (from-to)	128-131
Number of pages	4
Journal	Journal of Natural Products
Volume	66
Issue number	1
DOIs	https://doi.org/10.1021/np020308z
Publication status	Published - 2003 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np020308z

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title = "New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi",

abstract = "Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 μM.",

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AU - Uchiyama, Nahoko

AU - Kiuchi, Fumiyuki

AU - Ito, Michiho

AU - Honda, Gisho

AU - Takeda, Yoshio

AU - Khodzhimatov, Olimjon K.

AU - Ashurmetov, Ozodbek A.

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