New insight into reaction of iron(III)-peroxide adduct with alkanes: An alternative model for cytochrome P-450 and methane monooxygenase

Yuzo Nishida; Sayo Ito; Takashi Okuno; Shigeru Ohba

doi:10.1515/znc-1997-9-1008

New insight into reaction of iron(III)-peroxide adduct with alkanes: An alternative model for cytochrome P-450 and methane monooxygenase

Yuzo Nishida, Sayo Ito, Takashi Okuno, Shigeru Ohba

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A new mechanism for alkane functionalization by iron(III)-peroxide adducts was proposed, and the importance of electrophilic nature of the metal-peroxide adduct with η¹-coordination mode was emphasized. This idea suggests that formation of high-valent iron-oxo species occurs most likely when the metal-peroxide intermediate is activated through electronic interaction with both the peripheral organic group and substrate; the latter two act as an electron donor to the peroxide adduct.

Original language	English
Pages (from-to)	615-622
Number of pages	8
Journal	Zeitschrift fur Naturforschung Section C - Journal of Biosciences
Volume	52
Issue number	9-10
DOIs	https://doi.org/10.1515/znc-1997-9-1008
Publication status	Published - 1997
Externally published	Yes

Keywords

Activation of Peroxide Adduct
Alkane Functionalization
Electrophilicity of Metal-peroxide
Iron(III)-peroxide Adduct

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1515/znc-1997-9-1008

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T2 - An alternative model for cytochrome P-450 and methane monooxygenase

AU - Nishida, Yuzo

AU - Ito, Sayo

AU - Okuno, Takashi

AU - Ohba, Shigeru

PY - 1997

Y1 - 1997

N2 - A new mechanism for alkane functionalization by iron(III)-peroxide adducts was proposed, and the importance of electrophilic nature of the metal-peroxide adduct with η1-coordination mode was emphasized. This idea suggests that formation of high-valent iron-oxo species occurs most likely when the metal-peroxide intermediate is activated through electronic interaction with both the peripheral organic group and substrate; the latter two act as an electron donor to the peroxide adduct.

AB - A new mechanism for alkane functionalization by iron(III)-peroxide adducts was proposed, and the importance of electrophilic nature of the metal-peroxide adduct with η1-coordination mode was emphasized. This idea suggests that formation of high-valent iron-oxo species occurs most likely when the metal-peroxide intermediate is activated through electronic interaction with both the peripheral organic group and substrate; the latter two act as an electron donor to the peroxide adduct.

KW - Activation of Peroxide Adduct

KW - Alkane Functionalization

KW - Electrophilicity of Metal-peroxide

KW - Iron(III)-peroxide Adduct

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New insight into reaction of iron(III)-peroxide adduct with alkanes: An alternative model for cytochrome P-450 and methane monooxygenase

Abstract

Keywords

ASJC Scopus subject areas

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