New insight into reaction of iron(III)-peroxide adduct with alkanes

An alternative model for cytochrome P-450 and methane monooxygenase

Yuzo Nishida, Sayo Ito, Takashi Okuno, Shigeru Ohba

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A new mechanism for alkane functionalization by iron(III)-peroxide adducts was proposed, and the importance of electrophilic nature of the metal-peroxide adduct with η1-coordination mode was emphasized. This idea suggests that formation of high-valent iron-oxo species occurs most likely when the metal-peroxide intermediate is activated through electronic interaction with both the peripheral organic group and substrate; the latter two act as an electron donor to the peroxide adduct.

Original languageEnglish
Pages (from-to)615-622
Number of pages8
JournalZeitschrift fur Naturforschung Section C - Journal of Biosciences
Volume52
Issue number9-10
Publication statusPublished - 1997 Sep
Externally publishedYes

Fingerprint

methane monooxygenase
Alkanes
Peroxides
peroxides
cytochrome P-450
alkanes
Cytochrome P-450 Enzyme System
methane
Iron
iron
Metals
Metalloids
metals
electronics
electrons
Electrons
Substrates

Keywords

  • Activation of Peroxide Adduct
  • Alkane Functionalization
  • Electrophilicity of Metal-peroxide
  • Iron(III)-peroxide Adduct

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

New insight into reaction of iron(III)-peroxide adduct with alkanes : An alternative model for cytochrome P-450 and methane monooxygenase. / Nishida, Yuzo; Ito, Sayo; Okuno, Takashi; Ohba, Shigeru.

In: Zeitschrift fur Naturforschung Section C - Journal of Biosciences, Vol. 52, No. 9-10, 09.1997, p. 615-622.

Research output: Contribution to journalArticle

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