New isocoumarins, naphthoquinones, and a cleistanthane-type diterpene from Nectria pseudotrichia 120-1NP

Nanang Rudianto Ariefta; Priska Kristiana; Takako Aboshi; Tetsuya Murayama; Keitaro Tawaraya; Takuya Koseki; Naoaki Kurisawa; Ken ichi Kimura; Yoshihito Shiono

doi:10.1016/j.fitote.2018.03.012

New isocoumarins, naphthoquinones, and a cleistanthane-type diterpene from Nectria pseudotrichia 120-1NP

Nanang Rudianto Ariefta, Priska Kristiana, Takako Aboshi, Tetsuya Murayama, Keitaro Tawaraya, Takuya Koseki, Naoaki Kurisawa, Ken ichi Kimura, Yoshihito Shiono

Research output: Contribution to journal › Article › peer-review

Abstract

Four new compounds, namely, nectriapyrones A (2) and B (3), nectriaquinone B (5), and zythiostromic acid C (8), were isolated from the brown rice culture of Nectria pseudotrichia 120-1NP together with four known compounds (1, 4, 6, and 7). To the best of our knowledge, this is the first report of 4 from a natural source. Their structures were determined on the basis of 1D/2D-NMR spectroscopy and HRESITOFMS data. In addition, the absolute configuration of secondary alcohols in 8 were determined using modified Mosher's ester method. All isolated compounds were evaluated for their antimicrobials activity, phytotoxicity, and cytotoxicity.

Original language	English
Pages (from-to)	356-361
Number of pages	6
Journal	Fitoterapia
Volume	127
DOIs	https://doi.org/10.1016/j.fitote.2018.03.012
Publication status	Published - 2018 Jun
Externally published	Yes

Keywords

Cytotoxicity
Endophyte
Isocoumarin
Naphthoquinone
Nectria pseudotrichia
Zythiostromic acid

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.fitote.2018.03.012

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title = "New isocoumarins, naphthoquinones, and a cleistanthane-type diterpene from Nectria pseudotrichia 120-1NP",

abstract = "Four new compounds, namely, nectriapyrones A (2) and B (3), nectriaquinone B (5), and zythiostromic acid C (8), were isolated from the brown rice culture of Nectria pseudotrichia 120-1NP together with four known compounds (1, 4, 6, and 7). To the best of our knowledge, this is the first report of 4 from a natural source. Their structures were determined on the basis of 1D/2D-NMR spectroscopy and HRESITOFMS data. In addition, the absolute configuration of secondary alcohols in 8 were determined using modified Mosher's ester method. All isolated compounds were evaluated for their antimicrobials activity, phytotoxicity, and cytotoxicity.",

keywords = "Cytotoxicity, Endophyte, Isocoumarin, Naphthoquinone, Nectria pseudotrichia, Zythiostromic acid",

author = "Ariefta, {Nanang Rudianto} and Priska Kristiana and Takako Aboshi and Tetsuya Murayama and Keitaro Tawaraya and Takuya Koseki and Naoaki Kurisawa and Kimura, {Ken ichi} and Yoshihito Shiono",

note = "Funding Information: This work was partly supported by MEXT KAKENHI Grant Number JP15H05246 . Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = jun,

doi = "10.1016/j.fitote.2018.03.012",

language = "English",

volume = "127",

pages = "356--361",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier",

}

TY - JOUR

T1 - New isocoumarins, naphthoquinones, and a cleistanthane-type diterpene from Nectria pseudotrichia 120-1NP

AU - Ariefta, Nanang Rudianto

AU - Kristiana, Priska

AU - Aboshi, Takako

AU - Murayama, Tetsuya

AU - Tawaraya, Keitaro

AU - Koseki, Takuya

AU - Kurisawa, Naoaki

AU - Kimura, Ken ichi

AU - Shiono, Yoshihito

PY - 2018/6

Y1 - 2018/6

N2 - Four new compounds, namely, nectriapyrones A (2) and B (3), nectriaquinone B (5), and zythiostromic acid C (8), were isolated from the brown rice culture of Nectria pseudotrichia 120-1NP together with four known compounds (1, 4, 6, and 7). To the best of our knowledge, this is the first report of 4 from a natural source. Their structures were determined on the basis of 1D/2D-NMR spectroscopy and HRESITOFMS data. In addition, the absolute configuration of secondary alcohols in 8 were determined using modified Mosher's ester method. All isolated compounds were evaluated for their antimicrobials activity, phytotoxicity, and cytotoxicity.

AB - Four new compounds, namely, nectriapyrones A (2) and B (3), nectriaquinone B (5), and zythiostromic acid C (8), were isolated from the brown rice culture of Nectria pseudotrichia 120-1NP together with four known compounds (1, 4, 6, and 7). To the best of our knowledge, this is the first report of 4 from a natural source. Their structures were determined on the basis of 1D/2D-NMR spectroscopy and HRESITOFMS data. In addition, the absolute configuration of secondary alcohols in 8 were determined using modified Mosher's ester method. All isolated compounds were evaluated for their antimicrobials activity, phytotoxicity, and cytotoxicity.

KW - Cytotoxicity

KW - Endophyte

KW - Isocoumarin

KW - Naphthoquinone

KW - Nectria pseudotrichia

KW - Zythiostromic acid

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DO - 10.1016/j.fitote.2018.03.012

M3 - Article

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SN - 0367-326X

VL - 127

SP - 356

EP - 361

JO - Fitoterapia

JF - Fitoterapia

ER -

New isocoumarins, naphthoquinones, and a cleistanthane-type diterpene from Nectria pseudotrichia 120-1NP

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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