New Method for the Evaluation of in Vitro Dissolution Time and Disintegration Time

Yusuke Tanigawara, Kiyoshi Yamaoka, Terumichi Nakagawa, Toyozo Uno

Research output: Contribution to journalArticle

49 Citations (Scopus)


A new model-independent method is proposed for evaluating the in vitro dissolution time and disintegration time of solid dosage forms. The mean in vitro dissolution time (in vitro MDT) is defined as the first moment of the dissolution rate-time curve, that is, [formula omited], where dm/dt is the dissolution rate of a drug at time t. The mean in vitro disintegration time (in vitro MDIT) is defined by subtraction of MDT for drug powder from that for its tablet or capsule. The MDT is correlated with the parameters of several dissolution models.

Original languageEnglish
Pages (from-to)1088-1090
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Issue number3
Publication statusPublished - 1982
Externally publishedYes



  • convolution
  • mean in vitro disintegration time
  • mean in vitro dissolution time
  • model-independent
  • moments

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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