Abstract
A new model-independent method is proposed for evaluating the in vitro dissolution time and disintegration time of solid dosage forms. The mean in vitro dissolution time (in vitro MDT) is defined as the first moment of the dissolution rate-time curve, that is, [formula omited], where dm/dt is the dissolution rate of a drug at time t. The mean in vitro disintegration time (in vitro MDIT) is defined by subtraction of MDT for drug powder from that for its tablet or capsule. The MDT is correlated with the parameters of several dissolution models.
| Original language | English |
|---|---|
| Pages (from-to) | 1088-1090 |
| Number of pages | 3 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 30 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1982 |
| Externally published | Yes |
Keywords
- convolution
- mean in vitro disintegration time
- mean in vitro dissolution time
- model-independent
- moments
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery