New method of endoscopic full-thickness resection

A pilot study of non-exposed endoscopic wall-inversion surgery in an ex vivo porcine model

Osamu Goto, Takashi Mitsui, Mitsuhiro Fujishiro, Ikuo Wada, Nobuyuki Shimizu, Yasuyuki Seto, Kazuhiko Koike

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The indications for endoscopic full-thickness resection (EFTR) are limited because transmural communication during the entire procedure, causing tumor dissemination into the abdominal space, is inevitable. We invented a new method of EFTR without transmural communication, and explored its feasibility in an ex vivo porcine model. Three explanted porcine stomachs were used. First, markings around a model lesion were made with a flexible endoscope, and 0.9% normal saline with indigocarmine was injected into the submucosa around the markings. Second, a circumferential sero-muscular incision was made from the outside with an electrocautery knife, guided by the color of the submucosal injection and intragastric navigation with the endoscope. Third, the muscle layer was linearly sutured with the lesion inverted into the inside. Finally, a circumferential muco-submucosal incision was made with an electrocautery knife employed with the endoscope. The method was performed for 3 lesions (1 anterior wall, 1 lesser curve, and 1 posterior wall of the gastric body), and all lesions were successfully resected in en-bloc fashion. The mean size of the resected specimen was 4.5 cm in diameter. Neither perforation nor apparent air leakage was seen during or after the resection. Non-exposed endoscopic wall-inversion surgery (NEWS) is thought to be effective as a minimally invasive, and minimal-size endoluminal surgery for gastric submucosal tumors with or without ulceration, or even node-negative early gastric cancer that is difficult to resect by endoscopic submucosal dissection.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalGastric Cancer
Volume14
Issue number2
DOIs
Publication statusPublished - 2011 Jun
Externally publishedYes

Fingerprint

Endoscopes
Stomach
Electrocoagulation
Swine
Stomach Neoplasms
Neoplasms
Color
Air
Muscles
Injections

Keywords

  • Endoscopic full-thickness resection
  • Endoscopic submucosal dissection
  • Gastric neoplasm

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Cancer Research

Cite this

New method of endoscopic full-thickness resection : A pilot study of non-exposed endoscopic wall-inversion surgery in an ex vivo porcine model. / Goto, Osamu; Mitsui, Takashi; Fujishiro, Mitsuhiro; Wada, Ikuo; Shimizu, Nobuyuki; Seto, Yasuyuki; Koike, Kazuhiko.

In: Gastric Cancer, Vol. 14, No. 2, 06.2011, p. 183-187.

Research output: Contribution to journalArticle

Goto, Osamu ; Mitsui, Takashi ; Fujishiro, Mitsuhiro ; Wada, Ikuo ; Shimizu, Nobuyuki ; Seto, Yasuyuki ; Koike, Kazuhiko. / New method of endoscopic full-thickness resection : A pilot study of non-exposed endoscopic wall-inversion surgery in an ex vivo porcine model. In: Gastric Cancer. 2011 ; Vol. 14, No. 2. pp. 183-187.
@article{aa6fd68eae964e6e83a528882d121ab8,
title = "New method of endoscopic full-thickness resection: A pilot study of non-exposed endoscopic wall-inversion surgery in an ex vivo porcine model",
abstract = "The indications for endoscopic full-thickness resection (EFTR) are limited because transmural communication during the entire procedure, causing tumor dissemination into the abdominal space, is inevitable. We invented a new method of EFTR without transmural communication, and explored its feasibility in an ex vivo porcine model. Three explanted porcine stomachs were used. First, markings around a model lesion were made with a flexible endoscope, and 0.9{\%} normal saline with indigocarmine was injected into the submucosa around the markings. Second, a circumferential sero-muscular incision was made from the outside with an electrocautery knife, guided by the color of the submucosal injection and intragastric navigation with the endoscope. Third, the muscle layer was linearly sutured with the lesion inverted into the inside. Finally, a circumferential muco-submucosal incision was made with an electrocautery knife employed with the endoscope. The method was performed for 3 lesions (1 anterior wall, 1 lesser curve, and 1 posterior wall of the gastric body), and all lesions were successfully resected in en-bloc fashion. The mean size of the resected specimen was 4.5 cm in diameter. Neither perforation nor apparent air leakage was seen during or after the resection. Non-exposed endoscopic wall-inversion surgery (NEWS) is thought to be effective as a minimally invasive, and minimal-size endoluminal surgery for gastric submucosal tumors with or without ulceration, or even node-negative early gastric cancer that is difficult to resect by endoscopic submucosal dissection.",
keywords = "Endoscopic full-thickness resection, Endoscopic submucosal dissection, Gastric neoplasm",
author = "Osamu Goto and Takashi Mitsui and Mitsuhiro Fujishiro and Ikuo Wada and Nobuyuki Shimizu and Yasuyuki Seto and Kazuhiko Koike",
year = "2011",
month = "6",
doi = "10.1007/s10120-011-0014-8",
language = "English",
volume = "14",
pages = "183--187",
journal = "Gastric Cancer",
issn = "1436-3291",
publisher = "Springer Japan",
number = "2",

}

TY - JOUR

T1 - New method of endoscopic full-thickness resection

T2 - A pilot study of non-exposed endoscopic wall-inversion surgery in an ex vivo porcine model

AU - Goto, Osamu

AU - Mitsui, Takashi

AU - Fujishiro, Mitsuhiro

AU - Wada, Ikuo

AU - Shimizu, Nobuyuki

AU - Seto, Yasuyuki

AU - Koike, Kazuhiko

PY - 2011/6

Y1 - 2011/6

N2 - The indications for endoscopic full-thickness resection (EFTR) are limited because transmural communication during the entire procedure, causing tumor dissemination into the abdominal space, is inevitable. We invented a new method of EFTR without transmural communication, and explored its feasibility in an ex vivo porcine model. Three explanted porcine stomachs were used. First, markings around a model lesion were made with a flexible endoscope, and 0.9% normal saline with indigocarmine was injected into the submucosa around the markings. Second, a circumferential sero-muscular incision was made from the outside with an electrocautery knife, guided by the color of the submucosal injection and intragastric navigation with the endoscope. Third, the muscle layer was linearly sutured with the lesion inverted into the inside. Finally, a circumferential muco-submucosal incision was made with an electrocautery knife employed with the endoscope. The method was performed for 3 lesions (1 anterior wall, 1 lesser curve, and 1 posterior wall of the gastric body), and all lesions were successfully resected in en-bloc fashion. The mean size of the resected specimen was 4.5 cm in diameter. Neither perforation nor apparent air leakage was seen during or after the resection. Non-exposed endoscopic wall-inversion surgery (NEWS) is thought to be effective as a minimally invasive, and minimal-size endoluminal surgery for gastric submucosal tumors with or without ulceration, or even node-negative early gastric cancer that is difficult to resect by endoscopic submucosal dissection.

AB - The indications for endoscopic full-thickness resection (EFTR) are limited because transmural communication during the entire procedure, causing tumor dissemination into the abdominal space, is inevitable. We invented a new method of EFTR without transmural communication, and explored its feasibility in an ex vivo porcine model. Three explanted porcine stomachs were used. First, markings around a model lesion were made with a flexible endoscope, and 0.9% normal saline with indigocarmine was injected into the submucosa around the markings. Second, a circumferential sero-muscular incision was made from the outside with an electrocautery knife, guided by the color of the submucosal injection and intragastric navigation with the endoscope. Third, the muscle layer was linearly sutured with the lesion inverted into the inside. Finally, a circumferential muco-submucosal incision was made with an electrocautery knife employed with the endoscope. The method was performed for 3 lesions (1 anterior wall, 1 lesser curve, and 1 posterior wall of the gastric body), and all lesions were successfully resected in en-bloc fashion. The mean size of the resected specimen was 4.5 cm in diameter. Neither perforation nor apparent air leakage was seen during or after the resection. Non-exposed endoscopic wall-inversion surgery (NEWS) is thought to be effective as a minimally invasive, and minimal-size endoluminal surgery for gastric submucosal tumors with or without ulceration, or even node-negative early gastric cancer that is difficult to resect by endoscopic submucosal dissection.

KW - Endoscopic full-thickness resection

KW - Endoscopic submucosal dissection

KW - Gastric neoplasm

UR - http://www.scopus.com/inward/record.url?scp=79959376893&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959376893&partnerID=8YFLogxK

U2 - 10.1007/s10120-011-0014-8

DO - 10.1007/s10120-011-0014-8

M3 - Article

VL - 14

SP - 183

EP - 187

JO - Gastric Cancer

JF - Gastric Cancer

SN - 1436-3291

IS - 2

ER -