New neurons clear the path of astrocytic processes for their rapid migration in the adult brain

Naoko Kaneko, Oscar Marín, Masato Koike, Yuki Hirota, Yasuo Uchiyama, Jane Y. Wu, Qiang Lu, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, Hideyuki Okano, John L R Rubenstein, Kazunobu Sawamoto

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? Previous studies indicate that young neurons achieve this by migrating in chains through astrocytic tunnels. Here, we report that young migrating neurons actively control the formation and maintenance of their own migration route. New neurons secrete the diffusible protein Slit1, whose receptor, Robo, is expressed on astrocytes. We show that the Slit-Robo pathway is required for morphologic and organizational changes in astrocytes that result in the formation and maintenance of the astrocytic tunnels. Through this neuron-glia interaction, the new neurons regulate the formation of the astrocytic meshwork that is needed to enable their rapid and directional migration in adult brain.

Original languageEnglish
Pages (from-to)213-223
Number of pages11
JournalNeuron
Volume67
Issue number2
DOIs
Publication statusPublished - 2010 Jul

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Neurons
Brain
Neuroglia
Astrocytes
Maintenance
Organizational Innovation
Lateral Ventricles
Olfactory Bulb
Young Adult
Mammals
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kaneko, N., Marín, O., Koike, M., Hirota, Y., Uchiyama, Y., Wu, J. Y., ... Sawamoto, K. (2010). New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron, 67(2), 213-223. https://doi.org/10.1016/j.neuron.2010.06.018

New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. / Kaneko, Naoko; Marín, Oscar; Koike, Masato; Hirota, Yuki; Uchiyama, Yasuo; Wu, Jane Y.; Lu, Qiang; Tessier-Lavigne, Marc; Alvarez-Buylla, Arturo; Okano, Hideyuki; Rubenstein, John L R; Sawamoto, Kazunobu.

In: Neuron, Vol. 67, No. 2, 07.2010, p. 213-223.

Research output: Contribution to journalArticle

Kaneko, N, Marín, O, Koike, M, Hirota, Y, Uchiyama, Y, Wu, JY, Lu, Q, Tessier-Lavigne, M, Alvarez-Buylla, A, Okano, H, Rubenstein, JLR & Sawamoto, K 2010, 'New neurons clear the path of astrocytic processes for their rapid migration in the adult brain', Neuron, vol. 67, no. 2, pp. 213-223. https://doi.org/10.1016/j.neuron.2010.06.018
Kaneko, Naoko ; Marín, Oscar ; Koike, Masato ; Hirota, Yuki ; Uchiyama, Yasuo ; Wu, Jane Y. ; Lu, Qiang ; Tessier-Lavigne, Marc ; Alvarez-Buylla, Arturo ; Okano, Hideyuki ; Rubenstein, John L R ; Sawamoto, Kazunobu. / New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. In: Neuron. 2010 ; Vol. 67, No. 2. pp. 213-223.
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