Abstract
Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 μM (1), 36 μM (2), 34 μM (3), 34 μM (4), 66 μM (5), 66 μM (6), and >265 μM (7).
| Original language | English |
|---|---|
| Pages (from-to) | 1492-1494 |
| Number of pages | 3 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 52 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2004 Dec 1 |
| Externally published | Yes |
Keywords
- Norditerpene aldehyde
- Trypanocidal constituent
- Trypanosoma cruzi
- Verbenaceae
- Vitex trifolia
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery
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Cite this
Kiuchi, F., Matsuo, K., Ito, M., Qui, T. K., & Honda, G. (2004). New norditerpenoids with trypanocidal activity from Vitex trifolia. Chemical and Pharmaceutical Bulletin, 52(12), 1492-1494. https://doi.org/10.1248/cpb.52.1492