New norditerpenoids with trypanocidal activity from Vitex trifolia

Fumiyuki Kiuchi, Kenji Matsuo, Michiho Ito, Tran Kim Qui, Gisho Honda

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 μM (1), 36 μM (2), 34 μM (3), 34 μM (4), 66 μM (5), 66 μM (6), and >265 μM (7).

Original languageEnglish
Pages (from-to)1492-1494
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume52
Issue number12
DOIs
Publication statusPublished - 2004 Dec 1
Externally publishedYes

Keywords

  • Norditerpene aldehyde
  • Trypanocidal constituent
  • Trypanosoma cruzi
  • Verbenaceae
  • Vitex trifolia

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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