Abstract
Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 μM (1), 36 μM (2), 34 μM (3), 34 μM (4), 66 μM (5), 66 μM (6), and >265 μM (7).
| Original language | English |
|---|---|
| Pages (from-to) | 1492-1494 |
| Number of pages | 3 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 52 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2004 Dec |
| Externally published | Yes |
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Keywords
- Norditerpene aldehyde
- Trypanocidal constituent
- Trypanosoma cruzi
- Verbenaceae
- Vitex trifolia
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Chemistry(all)
- Pharmacology
Cite this
New norditerpenoids with trypanocidal activity from Vitex trifolia. / Kiuchi, Fumiyuki; Matsuo, Kenji; Ito, Michiho; Qui, Tran Kim; Honda, Gisho.
In: Chemical and Pharmaceutical Bulletin, Vol. 52, No. 12, 12.2004, p. 1492-1494.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New norditerpenoids with trypanocidal activity from Vitex trifolia
AU - Kiuchi, Fumiyuki
AU - Matsuo, Kenji
AU - Ito, Michiho
AU - Qui, Tran Kim
AU - Honda, Gisho
PY - 2004/12
Y1 - 2004/12
N2 - Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 μM (1), 36 μM (2), 34 μM (3), 34 μM (4), 66 μM (5), 66 μM (6), and >265 μM (7).
AB - Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 μM (1), 36 μM (2), 34 μM (3), 34 μM (4), 66 μM (5), 66 μM (6), and >265 μM (7).
KW - Norditerpene aldehyde
KW - Trypanocidal constituent
KW - Trypanosoma cruzi
KW - Verbenaceae
KW - Vitex trifolia
UR - http://www.scopus.com/inward/record.url?scp=21644482782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21644482782&partnerID=8YFLogxK
U2 - 10.1248/cpb.52.1492
DO - 10.1248/cpb.52.1492
M3 - Article
VL - 52
SP - 1492
EP - 1494
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 12
ER -