New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

Fumiyuki Kiuchi; Kenji Matsuo; Michiho Ito; Tran Kim Qui; Gisho Honda

doi:10.1248/cpb.52.1495

New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

Fumiyuki Kiuchi, Kenji Matsuo, Michiho Ito, Tran Kim Qui, Gisho Honda

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).

Original language	English
Pages (from-to)	1495-1496
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	12
DOIs	https://doi.org/10.1248/cpb.52.1495
Publication status	Published - 2004 Dec
Externally published	Yes

Keywords

Labiatae
Pogostemon cablin
Sesquiterpene hydroperoxide
Trypanocidal constitutent
Trypanosoma cruzi

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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title = "New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin",

abstract = "Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).",

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author = "Fumiyuki Kiuchi and Kenji Matsuo and Michiho Ito and Qui, {Tran Kim} and Gisho Honda",

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T1 - New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

AU - Kiuchi, Fumiyuki

AU - Matsuo, Kenji

AU - Ito, Michiho

AU - Qui, Tran Kim

AU - Honda, Gisho

PY - 2004/12

Y1 - 2004/12

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KW - Labiatae

KW - Pogostemon cablin

KW - Sesquiterpene hydroperoxide

KW - Trypanocidal constitutent

KW - Trypanosoma cruzi

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New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

Abstract

Keywords

ASJC Scopus subject areas

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