Abstract
Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).
Original language | English |
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Pages (from-to) | 1495-1496 |
Number of pages | 2 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 52 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2004 Dec |
Externally published | Yes |
Keywords
- Labiatae
- Pogostemon cablin
- Sesquiterpene hydroperoxide
- Trypanocidal constitutent
- Trypanosoma cruzi
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery