Abstract
Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).
| Original language | English |
|---|---|
| Pages (from-to) | 1495-1496 |
| Number of pages | 2 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 52 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2004 Dec 1 |
| Externally published | Yes |
Keywords
- Labiatae
- Pogostemon cablin
- Sesquiterpene hydroperoxide
- Trypanocidal constitutent
- Trypanosoma cruzi
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery
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Cite this
Kiuchi, F., Matsuo, K., Ito, M., Qui, T. K., & Honda, G. (2004). New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin. Chemical and Pharmaceutical Bulletin, 52(12), 1495-1496. https://doi.org/10.1248/cpb.52.1495