New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

Fumiyuki Kiuchi; Kenji Matsuo; Michiho Ito; Tran Kim Qui; Gisho Honda

doi:10.1248/cpb.52.1495

New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

Fumiyuki Kiuchi, Kenji Matsuo, Michiho Ito, Tran Kim Qui, Gisho Honda

Research output: Contribution to journal › Article

40 Citations (Scopus)

Abstract

Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).

Original language	English
Pages (from-to)	1495-1496
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	12
DOIs	https://doi.org/10.1248/cpb.52.1495
Publication status	Published - 2004 Dec 1
Externally published	Yes

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Keywords

Labiatae
Pogostemon cablin
Sesquiterpene hydroperoxide
Trypanocidal constitutent
Trypanosoma cruzi

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Cite this

Kiuchi, F., Matsuo, K., Ito, M., Qui, T. K., & Honda, G. (2004). New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin. Chemical and Pharmaceutical Bulletin, 52(12), 1495-1496. https://doi.org/10.1248/cpb.52.1495

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10.1248/cpb.52.1495