Abstract
Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).
| Original language | English |
|---|---|
| Pages (from-to) | 1495-1496 |
| Number of pages | 2 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 52 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2004 Dec |
| Externally published | Yes |
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Keywords
- Labiatae
- Pogostemon cablin
- Sesquiterpene hydroperoxide
- Trypanocidal constitutent
- Trypanosoma cruzi
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Chemistry(all)
- Pharmacology
Cite this
New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin. / Kiuchi, Fumiyuki; Matsuo, Kenji; Ito, Michiho; Qui, Tran Kim; Honda, Gisho.
In: Chemical and Pharmaceutical Bulletin, Vol. 52, No. 12, 12.2004, p. 1495-1496.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin
AU - Kiuchi, Fumiyuki
AU - Matsuo, Kenji
AU - Ito, Michiho
AU - Qui, Tran Kim
AU - Honda, Gisho
PY - 2004/12
Y1 - 2004/12
N2 - Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).
AB - Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).
KW - Labiatae
KW - Pogostemon cablin
KW - Sesquiterpene hydroperoxide
KW - Trypanocidal constitutent
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=21644481492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21644481492&partnerID=8YFLogxK
U2 - 10.1248/cpb.52.1495
DO - 10.1248/cpb.52.1495
M3 - Article
C2 - 15577255
AN - SCOPUS:21644481492
VL - 52
SP - 1495
EP - 1496
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 12
ER -