New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

Fumiyuki Kiuchi; Kenji Matsuo; Michiho Ito; Tran Kim Qui; Gisho Honda

doi:10.1248/cpb.52.1495

New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

Fumiyuki Kiuchi, Kenji Matsuo, Michiho Ito, Tran Kim Qui, Gisho Honda

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).

Original language	English
Pages (from-to)	1495-1496
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	12
DOIs	https://doi.org/10.1248/cpb.52.1495
Publication status	Published - 2004 Dec
Externally published	Yes

Keywords

Labiatae
Pogostemon cablin
Sesquiterpene hydroperoxide
Trypanocidal constitutent
Trypanosoma cruzi

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.52.1495

Cite this

@article{528c5cf09f624b6eae73650f887336ef,

title = "New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin",

abstract = "Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).",

keywords = "Labiatae, Pogostemon cablin, Sesquiterpene hydroperoxide, Trypanocidal constitutent, Trypanosoma cruzi",

author = "Fumiyuki Kiuchi and Kenji Matsuo and Michiho Ito and Qui, {Tran Kim} and Gisho Honda",

year = "2004",

month = dec,

doi = "10.1248/cpb.52.1495",

language = "English",

volume = "52",

pages = "1495--1496",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "12",

}

TY - JOUR

T1 - New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

AU - Kiuchi, Fumiyuki

AU - Matsuo, Kenji

AU - Ito, Michiho

AU - Qui, Tran Kim

AU - Honda, Gisho

PY - 2004/12

Y1 - 2004/12

N2 - Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).

AB - Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).

KW - Labiatae

KW - Pogostemon cablin

KW - Sesquiterpene hydroperoxide

KW - Trypanocidal constitutent

KW - Trypanosoma cruzi

UR - http://www.scopus.com/inward/record.url?scp=21644481492&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21644481492&partnerID=8YFLogxK

U2 - 10.1248/cpb.52.1495

DO - 10.1248/cpb.52.1495

M3 - Article

C2 - 15577255

AN - SCOPUS:21644481492

VL - 52

SP - 1495

EP - 1496

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 12

ER -

New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this