TY - JOUR
T1 - New synthesis of (+)-and (-)-nojirimycin from myo-inositol
AU - Chida, Noritaka
AU - Furuno, Yuka
AU - Ogawa, Seiichiro
PY - 1989/1/1
Y1 - 1989/1/1
N2 - A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.
AB - A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.
UR - http://www.scopus.com/inward/record.url?scp=0024404338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024404338&partnerID=8YFLogxK
U2 - 10.1039/C39890001230
DO - 10.1039/C39890001230
M3 - Article
AN - SCOPUS:0024404338
SN - 1359-7345
SP - 1230
EP - 1231
JO - Chemical Communications
JF - Chemical Communications
IS - 17
ER -