Abstract
A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.
| Original language | English |
|---|---|
| Pages (from-to) | 1230-1231 |
| Number of pages | 2 |
| Journal | Journal of the Chemical Society, Chemical Communications |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 1989 Jan 1 |
ASJC Scopus subject areas
- Molecular Medicine
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Cite this
Chida, N., Furuno, Y., & Ogawa, S. (1989). New synthesis of (+)-and (-)-nojirimycin from myo-inositol. Journal of the Chemical Society, Chemical Communications, (17), 1230-1231. https://doi.org/10.1039/C39890001230