New synthesis of (+)-and (-)-nojirimycin from myo-inositol

Noritaka Chida, Yuka Furuno, Seiichiro Ogawa

Research output: Contribution to journal › Article

26 Citations (Scopus)

Abstract

A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.

Original languageEnglish
Pages (from-to)1230-1231
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number17
DOIs
Publication statusPublished - 1989

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Mannosidases
Glucosidases
Lactones
Inositol
Hydrogen
hydrogen sulfite
nojirimycin

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

New synthesis of (+)-and (-)-nojirimycin from myo-inositol. / Chida, Noritaka; Furuno, Yuka; Ogawa, Seiichiro.

In: Journal of the Chemical Society, Chemical Communications, No. 17, 1989, p. 1230-1231.

Research output: Contribution to journal › Article

Chida, N, Furuno, Y & Ogawa, S 1989, 'New synthesis of (+)-and (-)-nojirimycin from myo-inositol', Journal of the Chemical Society, Chemical Communications, no. 17, pp. 1230-1231. https://doi.org/10.1039/C39890001230
Chida N, Furuno Y, Ogawa S. New synthesis of (+)-and (-)-nojirimycin from myo-inositol. Journal of the Chemical Society, Chemical Communications. 1989;(17):1230-1231. https://doi.org/10.1039/C39890001230
Chida, Noritaka ; Furuno, Yuka ; Ogawa, Seiichiro. / New synthesis of (+)-and (-)-nojirimycin from myo-inositol. In: Journal of the Chemical Society, Chemical Communications. 1989 ; No. 17. pp. 1230-1231.
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