New synthesis of (+)-and (-)-nojirimycin from myo-inositol

Noritaka Chida; Yuka Furuno; Seiichiro Ogawa

doi:10.1039/C39890001230

New synthesis of (+)-and (-)-nojirimycin from myo-inositol

Noritaka Chida, Yuka Furuno, Seiichiro Ogawa

Department of Applied Chemistry

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27 Citations (Scopus)

Abstract

A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.

Original language	English
Pages (from-to)	1230-1231
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	17
DOIs	https://doi.org/10.1039/C39890001230
Publication status	Published - 1989 Jan 1

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ASJC Scopus subject areas

Molecular Medicine

Cite this

Chida, N., Furuno, Y., & Ogawa, S. (1989). New synthesis of (+)-and (-)-nojirimycin from myo-inositol. Journal of the Chemical Society, Chemical Communications, (17), 1230-1231. https://doi.org/10.1039/C39890001230

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Access to Document

10.1039/C39890001230