Abstract
A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.
Original language | English |
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Pages (from-to) | 1230-1231 |
Number of pages | 2 |
Journal | Journal of the Chemical Society, Chemical Communications |
Issue number | 17 |
DOIs | |
Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Molecular Medicine
Cite this
New synthesis of (+)-and (-)-nojirimycin from myo-inositol. / Chida, Noritaka; Furuno, Yuka; Ogawa, Seiichiro.
In: Journal of the Chemical Society, Chemical Communications, No. 17, 1989, p. 1230-1231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New synthesis of (+)-and (-)-nojirimycin from myo-inositol
AU - Chida, Noritaka
AU - Furuno, Yuka
AU - Ogawa, Seiichiro
PY - 1989
Y1 - 1989
N2 - A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.
AB - A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.
UR - http://www.scopus.com/inward/record.url?scp=0024404338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024404338&partnerID=8YFLogxK
U2 - 10.1039/C39890001230
DO - 10.1039/C39890001230
M3 - Article
AN - SCOPUS:0024404338
SP - 1230
EP - 1231
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 17
ER -