New transcutaneous sampling of glucose for patients with type II diabetes using an ion-sensitive field-effect transistor

Shinsuke Kayashima, Tsunenori Arai, Masayuki Noritake, Naokazu Nagata, Makoto Kikuchi, Narushi Ito, Yasuyoshi Matsumoto, Akio Kaneyoshi, Jun Kimura, Toshihide Kuriyama

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Blood glucose change during the 75-g oral glucose tolerance test (g OGTT) was monitored by suction effusion fluid (SEF) sampling in five patients with type II diabetes. SEF is a small volume of fluid sampled by sucking the stratum corneum-stripped skin by an absolute pressure of 400 mmHg without bleeding or subcutaneous hemorrhage. Serum glucose and SEF glucose in each 5-μl sample were measured by an ion-sensitive field-effect transistor (ISFET) glucose sensor. The coefficients of determination between the SEF and serum glucose change were between 0.759 and 0.964, and after adjusting sampling delay they became between 0.839 and 0.996, irrespective of the patient's age, diabetic history and diabetic complications. The damage to the sucked skin surface was mild with pressed mesh forms. Transcutaneous monitoring was achieved in diabetic patients with mild skin damage by the SEF sampling method.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalClinica Chimica Acta
Volume240
Issue number1
DOIs
Publication statusPublished - 1995 Aug 31

Keywords

  • Bio-sensor
  • Glucose monitoring
  • Interstitial fluid
  • Type II diabetes

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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    Kayashima, S., Arai, T., Noritake, M., Nagata, N., Kikuchi, M., Ito, N., Matsumoto, Y., Kaneyoshi, A., Kimura, J., & Kuriyama, T. (1995). New transcutaneous sampling of glucose for patients with type II diabetes using an ion-sensitive field-effect transistor. Clinica Chimica Acta, 240(1), 11-19. https://doi.org/10.1016/0009-8981(95)06122-5