NF-B, inflammation, immunity and cancer: Coming of age

Koji Taniguchi, Michael Karin

Research output: Contribution to journalReview article

362 Citations (Scopus)

Abstract

Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized by the broad cancer research community as a hallmark and cause of cancer. Here, we discuss how the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity.

Original languageEnglish
Pages (from-to)309-324
Number of pages16
JournalNature Reviews Immunology
Volume18
Issue number5
DOIs
Publication statusPublished - 2018 May 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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