Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids

Takanori Iwasaki, Kiyokazu Higashikawa, Vutukuri P. Reddy, Willbe W S Ho, Yukari Fujimoto, Koichi Fukase, Jun Terao, Hitoshi Kuniyasu, Nobuaki Kambe

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The knights who say Ni: A practical and convenient synthetic route to fatty acids involves the Ni-catalyzed alkyl-alkyl cross-coupling of bromoalkanoic acids and alkyl Grignard reagents in the presence of 1,3-butadiene as an additive (see scheme).

Original languageEnglish
Pages (from-to)2956-2960
Number of pages5
JournalChemistry - A European Journal
Volume19
Issue number9
DOIs
Publication statusPublished - 2013 Feb 25
Externally publishedYes

Fingerprint

Nickel
Butadiene
Fatty acids
Fatty Acids
Acids
1,3-butadiene

Keywords

  • additives
  • alkylation
  • C-C coupling
  • fatty acids
  • nickel

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents : A practical and versatile method for preparing fatty acids. / Iwasaki, Takanori; Higashikawa, Kiyokazu; Reddy, Vutukuri P.; Ho, Willbe W S; Fujimoto, Yukari; Fukase, Koichi; Terao, Jun; Kuniyasu, Hitoshi; Kambe, Nobuaki.

In: Chemistry - A European Journal, Vol. 19, No. 9, 25.02.2013, p. 2956-2960.

Research output: Contribution to journalArticle

Iwasaki, Takanori ; Higashikawa, Kiyokazu ; Reddy, Vutukuri P. ; Ho, Willbe W S ; Fujimoto, Yukari ; Fukase, Koichi ; Terao, Jun ; Kuniyasu, Hitoshi ; Kambe, Nobuaki. / Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents : A practical and versatile method for preparing fatty acids. In: Chemistry - A European Journal. 2013 ; Vol. 19, No. 9. pp. 2956-2960.
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AU - Reddy, Vutukuri P.

AU - Ho, Willbe W S

AU - Fujimoto, Yukari

AU - Fukase, Koichi

AU - Terao, Jun

AU - Kuniyasu, Hitoshi

AU - Kambe, Nobuaki

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