Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids

Takanori Iwasaki, Kiyokazu Higashikawa, Vutukuri P. Reddy, Willbe W.S. Ho, Yukari Fujimoto, Koichi Fukase, Jun Terao, Hitoshi Kuniyasu, Nobuaki Kambe

Research output: Contribution to journalArticle

21 Citations (Scopus)


The knights who say Ni: A practical and convenient synthetic route to fatty acids involves the Ni-catalyzed alkyl-alkyl cross-coupling of bromoalkanoic acids and alkyl Grignard reagents in the presence of 1,3-butadiene as an additive (see scheme).

Original languageEnglish
Pages (from-to)2956-2960
Number of pages5
JournalChemistry - A European Journal
Issue number9
Publication statusPublished - 2013 Feb 25



  • C-C coupling
  • additives
  • alkylation
  • fatty acids
  • nickel

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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