Nine Japanese patients with immotile-dyskinetic cilia syndrome

An ultrastructural study using tannic acid-containing fixation

Chikao Torikata, Takeshi Kawai, Shigeru Nogawa, Kazushige Ikeda, Koichi Shimizu, Chuichi Kijimoto

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Respiratory cilia and sperm flagella of nine Japanese patients with immotile-dyskinetic cilia syndrome were studied ultrastructurally by using a tannic acid-containing fixative. Respiratory cilia from two female patients with Kartagener's syndrome and one male patient with situs inversus and sinobronchitis were completely immotile and lacked both dynein arms. However, approximately 30% of the spermatozoa from the male patient were weakly motile. In four patients with immotile cilia syndrome without Kartagener's triad, immotile respiratory cilia generally lacked the inner dynein arms. Two clinically unusual cases, an 11-year-old boy and a 29-year-old woman with prolonged saccharin test, recurrent bronchitis, and bronchiectasia, possessed motile respiratory cilia. Ultrastructurally, both dynein arms were normal, but numerous defective central pairs (more than 50% and 70%, respectively) were seen, and the defect in the second case was similar to the transposition of microtubules reported by Sturgess et al (N Engl J Med 303:318-322, 1980). However, defects in the first case were unique and may be congenital. We propose a new type of dyskinetic cilia syndrome with defective central pairs. Additionally, nasal cilia from a 35-year-old man with immotile cilia syndrome contained excess large singlets within ciliary axonemes consisting of 17 protofilaments.

Original languageEnglish
Pages (from-to)830-836
Number of pages7
JournalHuman Pathology
Volume22
Issue number8
DOIs
Publication statusPublished - 1991

Fingerprint

Ciliary Motility Disorders
Cilia
Tannins
Dyneins
Kartagener Syndrome
Sperm Tail
Axoneme
Situs Inversus
Saccharin
Fixatives
Bronchitis
Nose
Microtubules
Spermatozoa

Keywords

  • immotile-dyskinetic cilia syndrome
  • respiratory cilia
  • tannic acid
  • ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Nine Japanese patients with immotile-dyskinetic cilia syndrome : An ultrastructural study using tannic acid-containing fixation. / Torikata, Chikao; Kawai, Takeshi; Nogawa, Shigeru; Ikeda, Kazushige; Shimizu, Koichi; Kijimoto, Chuichi.

In: Human Pathology, Vol. 22, No. 8, 1991, p. 830-836.

Research output: Contribution to journalArticle

Torikata, Chikao ; Kawai, Takeshi ; Nogawa, Shigeru ; Ikeda, Kazushige ; Shimizu, Koichi ; Kijimoto, Chuichi. / Nine Japanese patients with immotile-dyskinetic cilia syndrome : An ultrastructural study using tannic acid-containing fixation. In: Human Pathology. 1991 ; Vol. 22, No. 8. pp. 830-836.
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