Niobium(v)-catalyzed defluorinative triallylation of α,α,α-trifluorotoluene derivatives by triple C-F bond activation

Kodai Saito, Taishi Umi, Takayuki Yamada, Takuya Suga, Takahiko Akiyama

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The catalytic defluorinative triallylation of α,α,α-trifluorotoluene derivatives via C-F bond activation has been achieved by the use of the NbCl5 catalyst and allyltrimethylsilane as a nucleophile. Several control experiments have suggested the importance of the conjugation between the fluorine atoms and the carbocation center in this reaction.

Original languageEnglish
Pages (from-to)1767-1770
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number8
DOIs
Publication statusPublished - 2017
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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