Nitric oxide production inhibitory activity of flavonoids contained in trunk exudates of Dalbergia sissoo

Suraj Prakash Shrestha, Yuri Amano, Yuji Narukawa, Tadahiro Takeda

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32 Citations (Scopus)

Abstract

Methanolic extracts of trunk exudates of Dalbergia sissoo yielded two new open-chain neoflavonoids (1, 2), a new flavonoid (3), a new flavanone (4), and 26 known compounds. Their structures were elucidated by detailed spectroscopic analyses. The ability of the isolated compounds to prevent nitric oxide (NO) production by LPS-stimulated J774.1 cells was also studied. All of the isolated compounds except 4, formononetin, and zenognosin B exhibited significant activity in a concentration-dependent manner. Compounds 2 and 3 were among the most potent NO production inhibitors, with IC50 values of 3.19 and 6.22 μM, respectively, and compound 1 had an IC50 of 31.6 μM.

Original languageEnglish
Pages (from-to)98-101
Number of pages4
JournalJournal of Natural Products
Volume71
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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