Nitric oxide regulates NMDA-induced dopamine release in rat striatum

Mamoru Shibata, Nobuo Araki, Kouichi Ohta, Junichi Hamada, Kunio Shimazu, Yasuo Fukuuchi

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We investigated the effect of nitric oxide (NO) on N-methyl-D-aspartate (NMDA)-induced changes in levels of dopamine (DA) and its metabolite in the striatum using in vivo microdialysis. Local administration of 1 mM NMDA into the striatum significantly augmented DA release in the striatum. Simultaneous administration of .5 mM N(G)-nitro-L-arginine methyl ester (-NAME), a NO synthase inhibitor, into the striatum significantly potentiated NMDA-induced DA release. This effect of L-NAME was completely reversed in the presence of 50 mM L-arginine (L-Arg). Administration of 1 mM NMDA significantly decreased the levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). This effect of NMDA was not affected by concurrent administration of L-NAME. This study provides in vivo evidence for the involvement of NO in NMDA-induced DA release.

Original languageEnglish
Pages (from-to)605-608
Number of pages4
JournalNeuroReport
Volume7
Issue number2
Publication statusPublished - 1996

Fingerprint

N-Methylaspartate
Dopamine
Nitric Oxide
NG-Nitroarginine Methyl Ester
Homovanillic Acid
Microdialysis
Nitric Oxide Synthase
Arginine
Acids

Keywords

  • dihydroxyphenylacetic acid (DOPAC)
  • dopamine (DA)
  • homovanillic acid (HVA)
  • in vivo microdialysis
  • N-methyl-D-aspartate (NMDA)
  • neurotransmitter
  • nitric oxide
  • striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Shibata, M., Araki, N., Ohta, K., Hamada, J., Shimazu, K., & Fukuuchi, Y. (1996). Nitric oxide regulates NMDA-induced dopamine release in rat striatum. NeuroReport, 7(2), 605-608.

Nitric oxide regulates NMDA-induced dopamine release in rat striatum. / Shibata, Mamoru; Araki, Nobuo; Ohta, Kouichi; Hamada, Junichi; Shimazu, Kunio; Fukuuchi, Yasuo.

In: NeuroReport, Vol. 7, No. 2, 1996, p. 605-608.

Research output: Contribution to journalArticle

Shibata, M, Araki, N, Ohta, K, Hamada, J, Shimazu, K & Fukuuchi, Y 1996, 'Nitric oxide regulates NMDA-induced dopamine release in rat striatum', NeuroReport, vol. 7, no. 2, pp. 605-608.
Shibata M, Araki N, Ohta K, Hamada J, Shimazu K, Fukuuchi Y. Nitric oxide regulates NMDA-induced dopamine release in rat striatum. NeuroReport. 1996;7(2):605-608.
Shibata, Mamoru ; Araki, Nobuo ; Ohta, Kouichi ; Hamada, Junichi ; Shimazu, Kunio ; Fukuuchi, Yasuo. / Nitric oxide regulates NMDA-induced dopamine release in rat striatum. In: NeuroReport. 1996 ; Vol. 7, No. 2. pp. 605-608.
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