No association between the CNTF null mutation and schizophrenia or personality

Jun Nishiyama, Mamoru Tochigi, Shin Itoh, Takeshi Otowa, Chieko Kato, Tadashi Umekage, Kazuhisa Kohda, Takashi Ebisawa, Nobumasa Kato, Tsukasa Sasaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The ciliary neurotrophic factor (CNTF) is a neurotrophic cytokine that plays a critical role in neurodevelopment. On the basis of neurodevelopmental hypothesis, the CNTF gene has been a candidate locus for schizophrenia. Several studies have investigated the association between the null mutation of the gene and schizophrenia, however, with inconsistent results. In the present study, we investigated the association in 222 Japanese patients with schizophrenia and 237 controls. The association between the mutation and personality traits was also studied, to investigate the effect of the mutation in participants from the general population. As a result, no association was observed between the mutation and schizophrenia nor personality traits, evaluated by using the Revised NEO Personality Inventory scores. The present study did not provide evidence for the association between the CNTF gene and schizophrenia or personality traits in the Japanese population.

Original languageEnglish
Pages (from-to)217-219
Number of pages3
JournalPsychiatric Genetics
Volume16
Issue number5
DOIs
Publication statusPublished - 2006 Oct

Fingerprint

Ciliary Neurotrophic Factor
Personality
Schizophrenia
Mutation
Genes
Personality Inventory
Population
Cytokines

Keywords

  • Association study
  • Ciliary neurotrophic factor
  • Mutation
  • Personality traits
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

Cite this

Nishiyama, J., Tochigi, M., Itoh, S., Otowa, T., Kato, C., Umekage, T., ... Sasaki, T. (2006). No association between the CNTF null mutation and schizophrenia or personality. Psychiatric Genetics, 16(5), 217-219. https://doi.org/10.1097/01.ypg.0000242189.05656.9d

No association between the CNTF null mutation and schizophrenia or personality. / Nishiyama, Jun; Tochigi, Mamoru; Itoh, Shin; Otowa, Takeshi; Kato, Chieko; Umekage, Tadashi; Kohda, Kazuhisa; Ebisawa, Takashi; Kato, Nobumasa; Sasaki, Tsukasa.

In: Psychiatric Genetics, Vol. 16, No. 5, 10.2006, p. 217-219.

Research output: Contribution to journalArticle

Nishiyama, J, Tochigi, M, Itoh, S, Otowa, T, Kato, C, Umekage, T, Kohda, K, Ebisawa, T, Kato, N & Sasaki, T 2006, 'No association between the CNTF null mutation and schizophrenia or personality', Psychiatric Genetics, vol. 16, no. 5, pp. 217-219. https://doi.org/10.1097/01.ypg.0000242189.05656.9d
Nishiyama, Jun ; Tochigi, Mamoru ; Itoh, Shin ; Otowa, Takeshi ; Kato, Chieko ; Umekage, Tadashi ; Kohda, Kazuhisa ; Ebisawa, Takashi ; Kato, Nobumasa ; Sasaki, Tsukasa. / No association between the CNTF null mutation and schizophrenia or personality. In: Psychiatric Genetics. 2006 ; Vol. 16, No. 5. pp. 217-219.
@article{a3009f2894a94deaa0677c24293dc99c,
title = "No association between the CNTF null mutation and schizophrenia or personality",
abstract = "The ciliary neurotrophic factor (CNTF) is a neurotrophic cytokine that plays a critical role in neurodevelopment. On the basis of neurodevelopmental hypothesis, the CNTF gene has been a candidate locus for schizophrenia. Several studies have investigated the association between the null mutation of the gene and schizophrenia, however, with inconsistent results. In the present study, we investigated the association in 222 Japanese patients with schizophrenia and 237 controls. The association between the mutation and personality traits was also studied, to investigate the effect of the mutation in participants from the general population. As a result, no association was observed between the mutation and schizophrenia nor personality traits, evaluated by using the Revised NEO Personality Inventory scores. The present study did not provide evidence for the association between the CNTF gene and schizophrenia or personality traits in the Japanese population.",
keywords = "Association study, Ciliary neurotrophic factor, Mutation, Personality traits, Schizophrenia",
author = "Jun Nishiyama and Mamoru Tochigi and Shin Itoh and Takeshi Otowa and Chieko Kato and Tadashi Umekage and Kazuhisa Kohda and Takashi Ebisawa and Nobumasa Kato and Tsukasa Sasaki",
year = "2006",
month = "10",
doi = "10.1097/01.ypg.0000242189.05656.9d",
language = "English",
volume = "16",
pages = "217--219",
journal = "Psychiatric Genetics",
issn = "0955-8829",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - No association between the CNTF null mutation and schizophrenia or personality

AU - Nishiyama, Jun

AU - Tochigi, Mamoru

AU - Itoh, Shin

AU - Otowa, Takeshi

AU - Kato, Chieko

AU - Umekage, Tadashi

AU - Kohda, Kazuhisa

AU - Ebisawa, Takashi

AU - Kato, Nobumasa

AU - Sasaki, Tsukasa

PY - 2006/10

Y1 - 2006/10

N2 - The ciliary neurotrophic factor (CNTF) is a neurotrophic cytokine that plays a critical role in neurodevelopment. On the basis of neurodevelopmental hypothesis, the CNTF gene has been a candidate locus for schizophrenia. Several studies have investigated the association between the null mutation of the gene and schizophrenia, however, with inconsistent results. In the present study, we investigated the association in 222 Japanese patients with schizophrenia and 237 controls. The association between the mutation and personality traits was also studied, to investigate the effect of the mutation in participants from the general population. As a result, no association was observed between the mutation and schizophrenia nor personality traits, evaluated by using the Revised NEO Personality Inventory scores. The present study did not provide evidence for the association between the CNTF gene and schizophrenia or personality traits in the Japanese population.

AB - The ciliary neurotrophic factor (CNTF) is a neurotrophic cytokine that plays a critical role in neurodevelopment. On the basis of neurodevelopmental hypothesis, the CNTF gene has been a candidate locus for schizophrenia. Several studies have investigated the association between the null mutation of the gene and schizophrenia, however, with inconsistent results. In the present study, we investigated the association in 222 Japanese patients with schizophrenia and 237 controls. The association between the mutation and personality traits was also studied, to investigate the effect of the mutation in participants from the general population. As a result, no association was observed between the mutation and schizophrenia nor personality traits, evaluated by using the Revised NEO Personality Inventory scores. The present study did not provide evidence for the association between the CNTF gene and schizophrenia or personality traits in the Japanese population.

KW - Association study

KW - Ciliary neurotrophic factor

KW - Mutation

KW - Personality traits

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=33748748875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748748875&partnerID=8YFLogxK

U2 - 10.1097/01.ypg.0000242189.05656.9d

DO - 10.1097/01.ypg.0000242189.05656.9d

M3 - Article

C2 - 16969278

AN - SCOPUS:33748748875

VL - 16

SP - 217

EP - 219

JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 5

ER -