No Evidence of Association between Structural Polymorphism at the Dopamine D3 Receptor Locus and Alcoholism in the Japanese

Susumu Higuchi, Taro Muramatsu, Sachio Matsushita, Masanobu Murayama

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Dopaminergic systems mediate reward mechanisms and are involved in reinforcing self-administration of dependence-forming substances, including alcohol. Studies have reported that polymorphisms of the dopamine D2 receptor, whose structure and function are similar to those of the dopamine D3 receptor, increase the susceptibility to alcoholism. These observations led to the examination of the possible association between a structural polymorphism of the D3 receptor gene and alcoholism. Genotyping results, employing a PCR-RFLP method, showed no difference in allele and genotype frequencies of the D3 BalI polymorphism (Ser9/Gly9) between Japanese alcoholics and controls. Moreover, these frequencies were not altered in alcoholics with inactive aldehyde dehydrogenase-2 (ALDH2), a well-defined negative risk factor for alcoholism. These results strongly suggest that the dopamine D3 receptor is not associated with alcoholism.

Original languageEnglish
Pages (from-to)412-414
Number of pages3
JournalAmerican Journal of Medical Genetics - Seminars in Medical Genetics
Volume67
Issue number4
DOIs
Publication statusPublished - 1996 Jul 26
Externally publishedYes

Keywords

  • Alcoholism
  • Association
  • Dopamine D3 receptor
  • Polymorphism

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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