Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41

Shun Saito, Shiina Suzuki, Midori A. Arai

Research output: Contribution to journalArticlepeer-review

Abstract

The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and not at the standard temperature. We previously designated this type of compound as a “heat shock metabolite” (HSM). NMR and MS analytical techniques were used to determine that the chemical structure of 1 comprised a methylated-oxazole ring and a linear chain moiety modified with a terminal amide group. Thus, 1 was shown to be a new curromycin analog, which we have designated noaoxazole (1). Compound 1 weakly activated Notch signal reporter activity without exhibiting cytotoxicity against assay cells at the same concentration.

Original languageEnglish
Pages (from-to)509-513
Number of pages5
JournalJournal of Antibiotics
Volume75
Issue number9
DOIs
Publication statusPublished - 2022 Sep

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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