NOD-like receptors

Role in innate immunity and inflammatory disease

Grace Chen, Michael H. Shaw, Yungi Kim, Gabriel Nuñez

Research output: Contribution to journalReview article

411 Citations (Scopus)

Abstract

The NOD-like receptors (NLRs) are a specialized group of intracellular receptors that represent a key component of the host innate immune system. Since the discovery of the first NLR almost 10 years ago, the study of this special class of microbial sensors has burgeoned; consequently, a better understanding of the mechanism by which these receptors recognize microbes and other danger signals and of how they activate inflammatory signaling pathways has emerged. Moreover, in addition to their primary role in host defense against invading pathogens, their ability to regulate nuclear factor-kappa B (NF-κB) signaling, interleukin-1-beta (IL-1β) production, and cell death indicates that they are crucial to the pathogenesis of a variety of inflammatory human diseases.

Original languageEnglish
Pages (from-to)365-398
Number of pages34
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume4
DOIs
Publication statusPublished - 2009 Feb
Externally publishedYes

Fingerprint

Innate Immunity
receptors
NF-kappa B
Interleukin-1beta
Immune System
Cell Death
interleukin-1
human diseases
cell death
pathogenesis
microorganisms
NLR Proteins
innate immunity
pathogens

Keywords

  • Caspase-1
  • Crohn's disease
  • IL-1
  • NLRP3
  • NOD2

ASJC Scopus subject areas

  • Plant Science
  • Medicine(all)

Cite this

NOD-like receptors : Role in innate immunity and inflammatory disease. / Chen, Grace; Shaw, Michael H.; Kim, Yungi; Nuñez, Gabriel.

In: Annual Review of Pathology: Mechanisms of Disease, Vol. 4, 02.2009, p. 365-398.

Research output: Contribution to journalReview article

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