NOD-like receptors: Role in innate immunity and inflammatory disease

Grace Chen, Michael H. Shaw, Yun Gi Kim, Gabriel Nuñez

Research output: Contribution to journalReview articlepeer-review

458 Citations (Scopus)

Abstract

The NOD-like receptors (NLRs) are a specialized group of intracellular receptors that represent a key component of the host innate immune system. Since the discovery of the first NLR almost 10 years ago, the study of this special class of microbial sensors has burgeoned; consequently, a better understanding of the mechanism by which these receptors recognize microbes and other danger signals and of how they activate inflammatory signaling pathways has emerged. Moreover, in addition to their primary role in host defense against invading pathogens, their ability to regulate nuclear factor-kappa B (NF-κB) signaling, interleukin-1-beta (IL-1β) production, and cell death indicates that they are crucial to the pathogenesis of a variety of inflammatory human diseases.

Original languageEnglish
Pages (from-to)365-398
Number of pages34
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume4
DOIs
Publication statusPublished - 2009 Feb
Externally publishedYes

Keywords

  • Caspase-1
  • Crohn's disease
  • IL-1
  • NLRP3
  • NOD2

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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