Nodular regenerative hyperplasia of the liver SPECT evaluation with Tc- 99m stannous colloid and Tc-99m neoglycoalbumin

W. Yamamoto, N. Shuke, Y. Saito, K. Usui, K. Komura, A. Ishizaki, Hidenori Ojima, T. Aburano

Research output: Contribution to journalArticle

Abstract

The authors describe a case of nodular regenerative hyperplasia of the liver and its findings on liver SPECT with Tc-99m radiocolloid and Tc-99m neoglycoalbumin. A 22-year-old woman with systemic lupus erythematosus was hospitalized for intractable thrombocytopenia. A diagnostic work-up including CT revealed multiple liver nodules and portal hypertension with splenomegaly, suggesting hypersplenism as a cause of the thrombocytopenia. Liver SPECT with Kupffer cell-oriented Tc-99m stannous colloid and hepatocyte-oriented Tc-99m neoglycoalbumin showed increased uptake in the liver nodules, indicating the presence of Kupffer cells and hepatocytes. The patient underwent splenectomy and wedge liver biopsy. Pathologic analysis of the liver specimen revealed many hyperplastic nodules and sinusoidal congestion without cirrhosis. Based on these histopathologic features, the diagnosis of nodular regenerative hyperplasia of the liver was made.

Original languageEnglish
Pages (from-to)806-808
Number of pages3
JournalClinical Nuclear Medicine
Volume24
Issue number10
DOIs
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Colloids
Single-Photon Emission-Computed Tomography
Hyperplasia
Liver
Kupffer Cells
Thrombocytopenia
Hepatocytes
Hypersplenism
Splenomegaly
Portal Hypertension
Splenectomy
Systemic Lupus Erythematosus
Fibrosis
Biopsy

Keywords

  • Nodular Regenerative Hyperplasia of the Liver
  • SPECT
  • Tc- 99m Stannous Colloid
  • Tc-99m Neoglycoalbumin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Nodular regenerative hyperplasia of the liver SPECT evaluation with Tc- 99m stannous colloid and Tc-99m neoglycoalbumin. / Yamamoto, W.; Shuke, N.; Saito, Y.; Usui, K.; Komura, K.; Ishizaki, A.; Ojima, Hidenori; Aburano, T.

In: Clinical Nuclear Medicine, Vol. 24, No. 10, 1999, p. 806-808.

Research output: Contribution to journalArticle

Yamamoto, W. ; Shuke, N. ; Saito, Y. ; Usui, K. ; Komura, K. ; Ishizaki, A. ; Ojima, Hidenori ; Aburano, T. / Nodular regenerative hyperplasia of the liver SPECT evaluation with Tc- 99m stannous colloid and Tc-99m neoglycoalbumin. In: Clinical Nuclear Medicine. 1999 ; Vol. 24, No. 10. pp. 806-808.
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