TY - JOUR
T1 - Nodular regenerative hyperplasia of the liver SPECT evaluation with Tc- 99m stannous colloid and Tc-99m neoglycoalbumin
AU - Yamamoto, W.
AU - Shuke, N.
AU - Saito, Y.
AU - Usui, K.
AU - Komura, K.
AU - Ishizaki, A.
AU - Ojima, H.
AU - Aburano, T.
PY - 1999/10/4
Y1 - 1999/10/4
N2 - The authors describe a case of nodular regenerative hyperplasia of the liver and its findings on liver SPECT with Tc-99m radiocolloid and Tc-99m neoglycoalbumin. A 22-year-old woman with systemic lupus erythematosus was hospitalized for intractable thrombocytopenia. A diagnostic work-up including CT revealed multiple liver nodules and portal hypertension with splenomegaly, suggesting hypersplenism as a cause of the thrombocytopenia. Liver SPECT with Kupffer cell-oriented Tc-99m stannous colloid and hepatocyte-oriented Tc-99m neoglycoalbumin showed increased uptake in the liver nodules, indicating the presence of Kupffer cells and hepatocytes. The patient underwent splenectomy and wedge liver biopsy. Pathologic analysis of the liver specimen revealed many hyperplastic nodules and sinusoidal congestion without cirrhosis. Based on these histopathologic features, the diagnosis of nodular regenerative hyperplasia of the liver was made.
AB - The authors describe a case of nodular regenerative hyperplasia of the liver and its findings on liver SPECT with Tc-99m radiocolloid and Tc-99m neoglycoalbumin. A 22-year-old woman with systemic lupus erythematosus was hospitalized for intractable thrombocytopenia. A diagnostic work-up including CT revealed multiple liver nodules and portal hypertension with splenomegaly, suggesting hypersplenism as a cause of the thrombocytopenia. Liver SPECT with Kupffer cell-oriented Tc-99m stannous colloid and hepatocyte-oriented Tc-99m neoglycoalbumin showed increased uptake in the liver nodules, indicating the presence of Kupffer cells and hepatocytes. The patient underwent splenectomy and wedge liver biopsy. Pathologic analysis of the liver specimen revealed many hyperplastic nodules and sinusoidal congestion without cirrhosis. Based on these histopathologic features, the diagnosis of nodular regenerative hyperplasia of the liver was made.
KW - Nodular Regenerative Hyperplasia of the Liver
KW - SPECT
KW - Tc- 99m Stannous Colloid
KW - Tc-99m Neoglycoalbumin
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U2 - 10.1097/00003072-199910000-00020
DO - 10.1097/00003072-199910000-00020
M3 - Article
AN - SCOPUS:0032877185
SN - 0363-9762
VL - 24
SP - 806
EP - 808
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
IS - 10
ER -